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CT features of abdominal plasma cell neoplasms

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Abstract

The aim of this study was to describe the CT features of abdominal plasma cell neoplasms. We reviewed CT imaging findings in 11 patients (seven men, four women; mean age 62 years) with plasma cell neoplasms and abdominal involvement. Helical CT of the entire abdomen and pelvis was performed following intravenous administration of contrast material. Images were analyzed in consensus by two radiologists. Diagnoses were made from biopsy, surgery and/or clinical follow-up findings. Multiple myeloma was found in seven patients and extramedullary plasmacytoma in four patients. All patients with multiple myeloma had multifocal disease with involvement of perirenal space (4/7), retroperitoneal and pelvic lymph nodes (3/7), peritoneum (3/7), liver (2/7), subcutaneous tissues (2/7) and kidney (1/7). In three of the four patients with extramedullary plasmacytoma, a single site was involved, namely stomach, vagina and retroperitoneum. In the fourth patient, a double site of abdominal involvement was observed with rectal and jejunal masses. Plasma cell neoplasm should be considered in the differential diagnosis of single or multiple enhancing masses in the abdomen or pelvis. Abdominal plasma cell neoplasms were most frequently seen as well-defined enhancing masses (10/11).

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References

  1. Corwin J, Lindberg RD (1979) Solitary plasmocytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer 43:1007–1013

    Google Scholar 

  2. Knowling MA, Harwood AR, Bergsagel DE (1983) Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol 1:255–262

    Google Scholar 

  3. Soesan M, Paccagnella A, Chiarion-Sileni V et al. (1992) Extramedullary plasmacytoma: clinical behaviour and response to treatment. Ann Oncol 3:51–57

    Google Scholar 

  4. Kapadia SB (1980) Multiple myeloma: a clinicopathologic study of 62 consecutively autopsied cases. Medicine 59:380–392

    Google Scholar 

  5. Oshima K, Kanda Y, Nannya Y et al. (2001) Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol 67:1–5

    Article  Google Scholar 

  6. Alexiou C, Kau RJ, Dietzfelbinger H et al. (1999) Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer 85:2305–2314

    Google Scholar 

  7. Holland J, Trenkner DA, Wasserman TH, Fineberg B (1992) Plasmacytoma. Treatment results and conversion to myeloma. Cancer 69:1513–1517

    Google Scholar 

  8. Sukpanichnant S, Cousar JB, Leelasiri A, Graber SE, Greer JP, Collins RD (1994) Diagnostic criteria and histologic grading in multiple myeloma: histologic and immunohistologic analysis of 176 cases with clinical correlation. Hum Pathol 25:308–318

    Article  Google Scholar 

  9. Foerster J (1993) Multiple myeloma. In: Lee R, Bithell T, Foerster J et al. (eds) Wintrobe’s clinical haematology, vol. 2. Lea and Febiger, Philadelphia, pp 2219–2249

    Google Scholar 

  10. Pasmantier MW, Azar HA (1969) Extraskeletal spread in multiple plasma cell myeloma. A review of 57 autopsied cases. Cancer 23:167–174

    Google Scholar 

  11. Chemlal K, Couvelard A, Grange MJ et al. (1999) Nodular lesions of the liver revealing multiple myeloma. Leuk Lymphoma 33:389–392

    Google Scholar 

  12. Moulopoulos LA, Granfield CA, Dimopoulos MA, Kim EE, Alexanian R, Libshitz HI (1993) Extraosseous multiple myeloma: imaging features. Am J Roentgenol 161:1083–1087

    Google Scholar 

  13. Thiruvengadam R, Penetrante RB, Goolsby HJ, Silk YN, Bernstein ZP (1990) Multiple myeloma presenting as space-occupying lesions of the liver. Cancer 65:2784–2786

    Google Scholar 

  14. Voet D, Hamers J, Dendooven M et al. (1983) Non excretory myeloma presenting as a liver nodule on ultrasound. Acta Clin Belg 38:384–387

    Google Scholar 

  15. Mathieu D, Elouaer-Blanc L, Divine M, Rene E, Vasile N (1986) Hepatic plasmacytoma: sonographic and CT findings. J Comput Assist Tomogr 10:144–145

    Google Scholar 

  16. Ng P, Slater S, Radvan G, Price A (1999) Hepatic plasmacytomas: case report and review of imaging features. Australas Radiol 43:98–101

    Article  Google Scholar 

  17. Weichhold W, Labouyrie E, Merlio JP, Masson B, de Mascarel A (1995) Primary extramedullary plasmacytoma of the liver. A case report. Am J Surg Pathol 19:1197–1202

    Google Scholar 

  18. Talreja D, Slater LM, Dara P, Branson H, Armentrout SA (1980) Multiple myeloma complicated by myelomatous obstructive uropathy. Cancer 46:1893–1895

    Google Scholar 

  19. Jowitt SN, Jacobs A, Batman PA, Sapherson DA (1994) Atypical progression of multiple myeloma with extensive extramedullary disease. J Clin Pathol 47:269–271

    Google Scholar 

  20. Mitchell DG, Hill MC (1985) Obstructive jaundice due to multiple myeloma of the pancreatic head: CT evaluation. J Comput Assist Tomogr 9:1118–1119

    Google Scholar 

  21. Sered S, Nikolaidis P (2003) CT findings of perirenal plasmacytoma. Am J Roentgenol 181:888

    Google Scholar 

  22. Watanabe N, Morijiri M, Shimizu M et al. (2000) A case of retroperitoneal extramedullary plasmocytoma with multiple metastases. Clin Imaging 24:365–367

    Article  Google Scholar 

  23. Hayes DW, Bennet WA, Heck FJ (1952) Extramedullary lesions in multiple myeloma: review of the literature and pathologic studies. Arch Pathol 53:262–272

    Google Scholar 

  24. Karp SJ, Shareef D (1987) Ascites as a presenting feature multiple myeloma. J R Soc Med 80:182–184

    Google Scholar 

  25. Matsumoto A, Nagata K, Hamaguchi H, Taki K (1993) Solitary bone plasmacytoma terminally developed myeloma with multiple extramedullary lesions and myelomatous pleural effusion and ascites. Int J Hematol 59:59–65

    Google Scholar 

  26. Asahi H, Iwasa Y, Komatsu K et al. (2001) A case of plasmacytoma involving adrenal gland. Hinyokika Kiyo 47:629–631

    Google Scholar 

  27. Chan BK, Ranheim E, Jeffrey RB Jr (1999) Disseminated peritoneal plasmacytoma following cardiac transplantation. Abdom Imaging 24:508–510

    Article  Google Scholar 

  28. Di Prima F, Braccio F, Culella G, Torresin P (1987) Solitary extra-bone marrow plasmacytoma. Computerized tomography description of a case of mesenterico-ileal localization associated with gastric carcinoma. Radiol Med 73:584–586

    Google Scholar 

  29. Olson MC, Kalbhen CL, Posniak HV (1993) Pancreatic plasmacytomas in a patient with multiple myeloma: CT and ultrasound findings. Abdom Imaging 18:323–324

    Google Scholar 

  30. Torrubia S, Sabate JM, Palmer J, Martinez-Noguera A (2002) Plasmacytoma of the vagina: findings on CT and MR imaging. Am J Roentgenol 178:245–247

    Google Scholar 

  31. Yang C, Motteram R, Sandeman TF (1982) Extramedullary plasmacytoma of the bladder: a case report and review of literature. Cancer 50:146–149

    Google Scholar 

  32. Fendel EH, Fazio VW (1981) Extramedullary plasmacytoma of the small intestine: first case report of ileocolic fistula and review of the literature. Dis Colon Rectum 24:633–635

    Google Scholar 

  33. Hirata S, Yamaguchi K, Bandai S, Izumo A, Chijiwa K, Tanaka M (2002) Secondary extramedullary plasmocytoma involving the pancreas. J Hepatobiliary Pancreat Surg 9:111–115

    Article  Google Scholar 

  34. Yoon SE, Ha HK, Lee YS et al. (1999) Upper gastrointestinal series and CT findings of primary gastric plasmacytoma: report of two cases. Am J Roentgenol 173:1266–1268

    Google Scholar 

  35. Halliday T, Baxter G (2003) Lymphoma: pictoral review. I. Eur Radiol 13:1154–1164

    CAS  PubMed  Google Scholar 

  36. Halliday T, Baxter G (2003) Lymphoma: pictorial review. II. Eur Radiol 13:1224–1234

    CAS  PubMed  Google Scholar 

  37. Guermazi A, Meigin V, Brice P (2003) Extranodal lymphoplasmacytoid lymphoma: spectrum of disease. Eur Radiol 13:771–779

    Article  Google Scholar 

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Authors and Affiliations

  1. Hospital de Sant Pau, Universitat Autonoma de Barcelona, Avda. Sant Antoni M. Claret 167, 08025, Barcelona, Spain

    J. Monill, J. Pernas, E. Montserrat, C. Pérez, J. Clavero, A. Martinez-Noguera, R. Guerrero & S. Torrubia

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  1. J. Monill
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  2. J. Pernas
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  3. E. Montserrat
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  4. C. Pérez
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  6. A. Martinez-Noguera
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  7. R. Guerrero
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  8. S. Torrubia
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Correspondence to J. Monill.

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Monill, J., Pernas, J., Montserrat, E. et al. CT features of abdominal plasma cell neoplasms. Eur Radiol 15, 1705–1712 (2005). https://doi.org/10.1007/s00330-005-2642-z

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  • DOI: https://doi.org/10.1007/s00330-005-2642-z

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