Abstract
To assess prevalence and change of depression/anxiety symptoms in spondyloarthritis patients and feasibility of depression/anxiety questionnaires. 43 Patients with axial spondyloarthritis (axSpA) and 27 patients with psoriatic arthritis (PsA) were consecutively recruited. There were 34 patients on biologics and 36 patients on nonbiologics. Patients were not previously treated for depression. The demographic variables, pain, patient global assessment, laboratory, clinical findings, diseases activity scores, Beck Depression Inventory (BDI) and Depression Anxiety and Stress Scale—short version (DASS-21) were collected. The study visits were at the beginning, after 1 month, after 3 and after 6 months. In axSpA and PsA patients on biologics, BDI and DASS-21 were significantly lower compared to nonbiologics group during time. The axSpA patients on biologics had significantly lower BDI and depression severity by BDI at each time point and lower DASS-21 after 1, 3 and 6 months. BDI in PsA patients who received biological therapy was significantly lower after 3 and 6 months. In biologics groups, BDI significantly decreased after 3 months in axSpA patients and after 1 month in PsA patients. In axSpA patients, there was a medium correlation between BDI and axial pain, patient global assessment and disease activity scores. The biological therapy significantly affected the depression/anxiety symptoms in axSpA and PsA during time. BDI moderately correlated with pain and disease activity in axSpA. BDI and DASS-21 are easy to use in daily practice.
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SM participated in clinical assessment, designed, coordinated and continuously reviewed the study, participated in data management and statistical analysis and prepared the manuscript for publication. KV participated in data management, performed the statistical analysis and prepared the manuscript for publication. MZ participated in clinical assessment and drafting the manuscript. G. R. participated in clinical assessment analysis and interpretation of data, as well as in drafting the manuscript. ND participated in interpretation of data and drafting the manuscript.
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Authors S. Milutinovic, K.Veljkovic, M. Zlatanovic, G. Radunovic and N.Damjanov declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol was reviewed and approved by the Ethics Committee of the Institute of Rheumatology, Belgrade, Serbia (Protocol Number: 29/1-35/2016).
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Milutinovic, S., Veljkovic, K., Zlatanovic, M. et al. Depression/anxiety symptoms in axial spondyloarthritis and psoriatic arthritis patients in Serbia: a pilot study. Rheumatol Int 39, 1595–1605 (2019). https://doi.org/10.1007/s00296-019-04376-8
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DOI: https://doi.org/10.1007/s00296-019-04376-8