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Toll-like receptor-4 signaling: a new potential therapeutic pathway for rheumatoid arthritis

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Abstract

The Toll-like receptor-4 signaling (TLR-4) has been found to be over-expressed in rheumatoid arthritis (RA) synovium. Furthermore, it regulates the expression of pro-inflammatory cytokines. Based on the current evidences, TLR-4 may be a new potential therapeutic pathway for RA.

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Acknowledgments

This project was supported by grants from the National Natural Science Foundation of China (81072686; 81273526).

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. School of Pharmacy, Anhui Medical University, Mei Shan Road, Hefei, 230032, Anhui Province, China

    Xiaofeng Li, Tao Xu, Yarui Wang, Cheng Huang & Jun Li

Authors
  1. Xiaofeng Li
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  2. Tao Xu
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  3. Yarui Wang
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  4. Cheng Huang
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  5. Jun Li
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Corresponding author

Correspondence to Jun Li.

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Li, X., Xu, T., Wang, Y. et al. Toll-like receptor-4 signaling: a new potential therapeutic pathway for rheumatoid arthritis. Rheumatol Int 34, 1613–1614 (2014). https://doi.org/10.1007/s00296-013-2890-1

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  • DOI: https://doi.org/10.1007/s00296-013-2890-1

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