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Effects of bosentan on the skin lesions: an observational study from a single center in Japan

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Abstract

Effects of a dual endothelin receptor antagonist, bosentan on peripheral circulatioin and skin lesions as well as pulmonary arterial hypertension (PAH) were investigated in Japanese patients with connective tissue diseases (CTD). Fifteen patients with PAH associated with CTD [systemic sclerosis (SSc) 13, mixed connective tissue disease (MCTD) 2] were treated with bosentan for 40–96 weeks, and changes of exercise capacity (6-min walk distance and Borg’s dyspnea scale), cardio-pulmonary hemodynamics (right ventricular pressure, specific activity scale and cardiac index), Raynaud’s phenomenon, digital ulcers and dermal sclerosis were observed. Bosentan improved exercise capacity, had a positive effect on hemodynamic parameters, and was well tolerated as previously reported. After a median 8 weeks of treatment, 13 out of 15 patients had improved Raynaud’s phenomenon. Digital ulcers also improved after a median 12 weeks’ treatment in all of 8 patients. Modified Rodnan total skin score decreased from 21.0 ± 5.9 to 11.5 ± 3.9 in diffuse cutaneous SSc and from 17.0 ± 6.5 to 9.5 ± 4.5 in limited cutaneous SSc after 24 months’ treatment, reaching significance after 6 months in both groups. These data suggest that bosentan is effective for both PAH and peripheral vascular diseases in Japanese patients with CTD. The pathological background to the improvement in dermal sclerosis observed in this study should be further investigated.

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Acknowledgments

A part of this study was supported by a grant from The Osaka Medical Research Foundation for Incurable Diseases.

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Authors and Affiliations

  1. Department of Nephrology and Rheumatology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Masanori Funauchi, K. Kishimoto, H. Shimazu, Y. Nagare, S. Hino, T. Yano & K. Kinoshita

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  1. Masanori Funauchi
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  2. K. Kishimoto
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  3. H. Shimazu
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  4. Y. Nagare
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  5. S. Hino
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  6. T. Yano
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  7. K. Kinoshita
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Correspondence to Masanori Funauchi.

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Funauchi, M., Kishimoto, K., Shimazu, H. et al. Effects of bosentan on the skin lesions: an observational study from a single center in Japan. Rheumatol Int 29, 769–775 (2009). https://doi.org/10.1007/s00296-008-0789-z

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  • DOI: https://doi.org/10.1007/s00296-008-0789-z

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