Abstract
The objective of the present study was to investigate the relationship between leptin and bone mineral density in postmenopausal Turkish women. A total of 122 healthy postmenopausal women were enrolled in this cross-sectional study. Blood samples were obtained for analysis of serum leptin. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine, femoral neck and trochanter on the same day. Leptin levels was significantly correlated with BMD of L1–4 (P = 0.04), but not of femoral neck (P = 0.13), and trochanter (P = 0.39). However, Z scores of L1–4 (P = 0.009), femur neck (P = 0.009), and femur trochanter (P = 0.025) were positively correlated with leptin levels. In multiple linear regression analysis, leptin was not found to be a statistically significant independent predictor for BMD. Leptin was associated with BMD and Z scores at various body sites; however, it was not an independent predictor of BMD.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Considine RV, Sinha MK, Heiman ML et al (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292–295. doi:10.1056/NEJM199602013340503
Hosoda K, Masuzaki H, Ogawa Y et al (1996) Development of radioimmunoassay for human leptin. Biochem Biophys Res Commun 221:234–239
Iwamoto I, Douchi T, Kosha S, Murakami M, Fujino T, Nagata Y (2000) Relationships between serum leptin level and regional bone mineral density, bone metabolic markers in healthy women. Acta Obstet Gynecol Scand 79:1060–1064. doi:10.1034/j.1600-0412.2000.0790121060.x
Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL (1999) Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140:1630–1638. doi:10.1210/en.140.4.1630
Liu C, Grossmann A, Bain S et al (1997) Leptin stimulate cortical bone formation in obese (ob/ob) mice. J Bone Miner Res 12:s115. doi:10.1359/jbmr.1997.12.10.1691
Ogueh O, Sooranna S, Nicolaides KH, Johnson MR (2000) The relationship between leptin concentration and bone metabolism in the human fetus. J Clin Endocrinol Metab 85:1997–1999. doi:10.1210/jc.85.5.1997
Weiss LA, Barrett-Connor E, von Muhlen D, Clark P (2006) Leptin predicts BMD and bone resorption in older women but not older men: the Rancho Bernardo study. J Bone Miner Res 21:758–764. doi:10.1359/jbmr.060206
Zoico E, Zamboni M, Adami S et al (2003) Relationship between leptin levels and bone mineral density in the elderly. Clin Endocrinol 59:97–103. doi:10.1046/j.1365-2265.2003.01808.x
Goulding A, Taylor RW (1998) Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in postmenopausal women. Calcif Tissue Int 63:456–458. doi:10.1007/s002239900557
Sahin G, Polat G, Bagis S et al (2003) Body composition, bone mineral density, and circulating leptin levels in postmenopausal Turkish women. Rheumatol Int 23:87–91
Blum M, Harris SS, Must A et al (2003) Leptin body composition and bone mineral density in premenopausal women. Calsif Tissue Int 73:27–32. doi:10.1007/s00223-002-1019-4
Yamauchi M, Sugimoto T, Yamaguchi T et al (2001) Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women. Clin Endocrinol 55:341–347. doi:10.1046/j.1365-2265.2001.01361.x
Blain H, Vuillemin A, Guillemin F et al (2002) Serum leptin level is a predictor of bone mineral density in postmenopausal women. J Clin Endocrinol Metab 87:1030–1035. doi:10.1210/jc.87.3.1030
Chanprasertyothin S, Piaseu N, Chailurkit L, Rajatanavin R, Ongphiphadhanakul B (2005) Association of circulating leptin with bone mineral density in males and females. J Med Assoc Thai 88:655–659
Zhong N, Wu XP, Xu ZR et al (2005) Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta 351:161–168. doi:10.1016/j.cccn.2004.09.003
Ducy P, Amlilng M, Takeda S et al (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100:197–207. doi:10.1016/S0092-8674(00)81558-5
Iwaniec UT, Shearon CC, Heaney RP, Cullen DM, Yee JA (1998) Leptin increases number of mineralized bone nodules in vitro. J Bone Miner Res 13:s212
Masuzaki H, Ogawa Y, Isse N et al (1995) Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855–858. doi:10.2337/diabetes.44.7.855
Takeda S, Karsenty G (2001) Central control of bone formation. J Bone Miner Metab 19:195–198. doi:10.1007/s007740170042
Reid IR, Comish J (2004) Direct actions of leptin on bone remodeling. Calcif Tissue Int 74:313–316. doi:10.1007/s00223-002-0015-z
Cornish J, Callon KE, Bava U et al (2001) The direct actions of leptin on bone cells increase bone strength in vivo: an explanation of low frequency fracture rates in obesity (abstract). Bone 28:S88
Karsenty G (2001) Leptin controls bone formation through a hypothalamic relay. Recent Prog Horm Res 56:401–415. doi:10.1210/rp561401
Bassilana F, Susa M, Keller HJ et al (2000) Human mesenchymal stem cells undergoing osteogenic differentiation express leptin and functional leptin receptor (abstract). J Bone Miner Res 15:S378
Pasco JA, Henry MJ, Kotowicz MA et al (2001) Serum leptin levels are associated with bone mass in nonobese women. J Clin Endocrinol Metab 86:1884–1887. doi:10.1210/jc.86.5.1884
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Oguz, S., Tapisiz, O.L., Aytan, H. et al. Is leptin a significant predictor of bone mineral density in postmenopausal Turkish women?. Rheumatol Int 29, 393–396 (2009). https://doi.org/10.1007/s00296-008-0711-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-008-0711-8