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Which statin should be used together with colchicine? Clinical experience in three patients with nephrotic syndrome due to AA type amyloidosis

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Abstract

Colchicine and statins are well known drugs that cause myopathy and neuropathy. Co-administration of certain drugs with statins may increase myotoxic effect, causing myopathy and varying degrees of rhabdomyolysis. Therefore, it is very crucial to know which statin should be used during a combination therapy including colchicine and other drugs. We present three cases with AA amyloidosis secondary to familial Mediterranean fever, who developed neuromyopathy while receiving the combination of colchicine and statin. We also briefly discussed the different metabolic pathways of statins and colchicine when used together.

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Authors and Affiliations

  1. Division of Nephrology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    Garip Sahin & Ahmet Uğur Yalcin

  2. Division of Rheumatology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    Cengiz Korkmaz

  3. Visnelik M. Alifuat Güven C. Akasya S. 11/11, Eskisehir, Turkey

    Cengiz Korkmaz

Authors
  1. Garip Sahin
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  2. Cengiz Korkmaz
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  3. Ahmet Uğur Yalcin
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Correspondence to Cengiz Korkmaz.

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Sahin, G., Korkmaz, C. & Yalcin, A.U. Which statin should be used together with colchicine? Clinical experience in three patients with nephrotic syndrome due to AA type amyloidosis. Rheumatol Int 28, 289–291 (2008). https://doi.org/10.1007/s00296-007-0435-1

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  • DOI: https://doi.org/10.1007/s00296-007-0435-1

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