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Is measurement of IgM and IgA rheumatoid factors (RF) in juvenile rheumatoid arthritis clinically useful?

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Abstract

The prevalence and clinical relevance of IgM and IgA RF detected by ELISA were studied in 91 patients with juvenile rheumatoid arthritis (JRA) and 45 healthy children. IgM and IgA RF were detected, respectively, in 33 and 44% of the patients, compared to 6.7 and 15.6% of the healthy children (p = 0.001 and 0.0006, respectively). The frequency of IgM RF was significantly higher in patients with polyarticular (52%) as compared to systemic onset JRA (21%; p = 0.04). Five out of ninety-one patients and none of the control group were IgM RF positive by the latex test. High levels of IgM RF were detected more frequently in patients with active disease (p = 0.01) and positive latex agglutination test (p < 0.001) and had a marginally significant association with severe radiological deformities (p = 0.05). The presence of IgA RF was associated with active disease in polyarticular onset JRA children (p = 0.04). In conclusion, high levels of IgM RF and the detection of IgA RF can be useful in assessing clinical activity in a subset of patients with JRA.

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Authors and Affiliations

  1. Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, CEP: 14049-900, Ribeirao Preto, SP, Brazil

    Rosa A. Ferreira & Virginia P. L. Ferriani

  2. Department of Pediatrics, School of Medicine, Federal University of Uberlandia, Uberlandia, MG, Brazil

    Carlos H. M. Silva

  3. Department of Immunology, Microbiology and Parasitology, Federal University of Uberlandia, Uberlandia, MG, Brazil

    Deise A. O. Silva, Monica C. Sopelete & Jose R. Mineo

  4. Unit of Pediatric Rheumatology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

    Maria H. B. Kiss

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  1. Rosa A. Ferreira
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  2. Carlos H. M. Silva
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  3. Deise A. O. Silva
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  4. Monica C. Sopelete
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  5. Maria H. B. Kiss
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  6. Jose R. Mineo
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  7. Virginia P. L. Ferriani
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Correspondence to Virginia P. L. Ferriani.

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Ferreira, R.A., Silva, C.H.M., Silva, D.A.O. et al. Is measurement of IgM and IgA rheumatoid factors (RF) in juvenile rheumatoid arthritis clinically useful?. Rheumatol Int 27, 345–349 (2007). https://doi.org/10.1007/s00296-006-0221-5

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  • DOI: https://doi.org/10.1007/s00296-006-0221-5

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