Skip to main content

Advertisement

SpringerLink
Log in

Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The aim of this study was to determine how polymorphisms of transporters associated with transporter and antigen processing 1 (TAP1) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. We collected 88 patients with SLE and 104 healthy people for the control group. The polymorphisms were detected as a result of polymerase chain reaction (PCR)-based restriction analysis. Associations between SLE and TAP1 polymorphisms were evaluated. The results revealed no significant differences between the healthy individuals and SLE patients with TAP1-1 (Dpn II) and TAP1-2 (Acc I) polymorphisms (P=0.10 and 0.36, respectively). However, the G alleles of TAP1-1 and TAP1-2 were significantly more common than the A alleles in serositis of SLE patients (χ2=11.16 and P=0.004, χ2=8.10 and P=0.02, respectively).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fielder AHL, Walport MJ, Batchelor JR, Rynes RI, Black CM, Dodi IR (1983) Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility. Br Med J 286:425–428

    CAS  Google Scholar 

  2. Block SR, Winfield JB, Lockshin MD, D'Angelo WA, Christian CL (1975) Studies of twins with systemic lupus erythematosus. Am J Med 59:533–552

    CAS  PubMed  Google Scholar 

  3. Burch PRJ, Rowell NR (1993) Systemic lupus erythematosus and Klinefelter's syndrome. Lancet 1:1021

    Google Scholar 

  4. Jarvinen P, Kaprio J, Makitalo R, Koskenvuo M, Aho K (1992) Systemic lupus erythematosus and related systemic diseases in a nationwide twin cohort: an increased prevalence of diseases in MZ twins and concordance of disease features. J Intern Med 231:67–72

    CAS  PubMed  Google Scholar 

  5. Braciale TJ, Brasiale VL (1991) Antigen presentation: structural themes and functional variations. Immunol Today 12:124–129

    CAS  PubMed  Google Scholar 

  6. Malnati MS, Marti M, Lavaute T, Jaraquemada D, Biddision W, DeMars R (1992) Processing pathways for presentation of cytosolic antigen to MHC class II restricted T cells. Nature 357:702–704

    CAS  PubMed  Google Scholar 

  7. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277

    PubMed  Google Scholar 

  8. Kotzin BL (1996) Systemic lupus erythematosus. Cell 85:303–306

    CAS  PubMed  Google Scholar 

  9. Hahn BH (1997) An overview of the pathogenesis of systemic lupus erythematosus. In: Wallace DJ, Hahn BH (eds) Dubois lupus erythematosus. Fifth edn. Williams and Wilkins, Baltimore, pp 69–75

  10. Vyse TJ, Kotzin BL (1996) Genetic basis of systemic lupus erythematosus. Curr Opin Immunol 8:843–851

    Article  CAS  PubMed  Google Scholar 

  11. Arnett AE, Wilson WA (1997) Antiphospholipid antibodies. In: Wallace DJ, Hahn BH (eds) Dubois lupus erythematosus. Fifth edn. Williams and Wilkins, Baltimore, pp 471–491

  12. Powis SJ, Deverson EV, Coadwell WJ, Ciruela A, Huskisson NS, Smith H, Butcher GW, Howard JC (1992) Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature 357:211–215

    Google Scholar 

  13. Braciale TJ, Braciale VL (1991) Antigen presentation: structural themes and functional variations. Immunol Today 12:124–129

    CAS  PubMed  Google Scholar 

  14. Davis EJ, Donn RP, Hillarby MC, Grennan DM, Ollier WER (1994) Polymorphisms of the TAP2 transporter genes in systemic lupus erythematosus. Ann Rheum Dis 53:61–63

    PubMed  Google Scholar 

  15. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) Lack of association of IL-1 gene polymorphisms in Chinese patients with SLE. Rheumatol Int 21:173–175

    Article  CAS  PubMed  Google Scholar 

  16. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) Interleukin-1 receptor antagonist gene polymorphism in Chinese patients with systemic lupus erythematosus. Clin Rheumatol 21:255–257

    Article  PubMed  Google Scholar 

  17. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) No association of vitamin-D receptor gene start codon Fok I polymorphisms in Chinese patients with systemic lupus erythematosus. J Rheumatol 29:1211–1213

    CAS  PubMed  Google Scholar 

  18. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) Association of vitamin D receptor gene Bsm-I polymorphisms in Chinese patients with SLE. Lupus 11:31–34

    Article  CAS  PubMed  Google Scholar 

  19. Carrington M, Colonna M, Spies T, Stephens JC, Mann DL (1993) Haplotypic variation of the transporter associated with antigen processing (TAP) genes and their extension of HLA class II region haplotypes. Immunogenetics 37:266–273

    CAS  PubMed  Google Scholar 

  20. Powis SH, Tonks S, Mockridge I, Kelly AP, Bodmer JG, Trowsdale J (1993) Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics 37:373–380

    CAS  PubMed  Google Scholar 

  21. Savage DA, Ng SC, Howe HS, Ngai JLF, Darke C, Hui KM (1995) HLA and TAP association in Chinese systemic lupus erythematosus patients. Tissue Antigens 46:213–216

    CAS  PubMed  Google Scholar 

  22. Takeuchi F, Nakano K, Nabeta H, Hong GH, Kuwata S, Ito K (1996) Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE. Ann Rheum Dis 55:924–926

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan

    Chung-Ming Huang

  2. Chest Division, Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan

    Liang-Wen Hang

  3. Foo Yin Institute of Technology, Kaohsiung, Taiwan

    Chi-Lan Chen

  4. Department of Medicinal Genetics, China Medical College Hospital, No. 2 Yuh Der Road, Taichung, Taiwan

    Jer-Yuarn Wu & Fuu-Jen Tsai

Authors
  1. Chung-Ming Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Liang-Wen Hang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chi-Lan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jer-Yuarn Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fuu-Jen Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fuu-Jen Tsai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huang, CM., Hang, LW., Chen, CL. et al. Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan. Rheumatol Int 24, 130–132 (2004). https://doi.org/10.1007/s00296-003-0338-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-003-0338-8

Keywords

Search

Navigation