Abstract
Homologous recombination repairs discontinuities in DNA including single-strand gaps (SSGs) and double-strand breaks (DSBs). This commentary describes how the RecBCD and RecF pathways might be exchangeable for the repair of their respective DSB and SSG canonical substrates. In particular, I will discuss how the RecBCD pathway could engage in the repair of an SSG even when the latter is not associated with a DSB.
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Acknowledgments
The author is extremely grateful to his colleagues Luisa Laureti and Mauro Modesti for their many helpful comments and discussion. The work in the author’s laboratory is supported by Agence National de la Recherche grant GENOBLOCK (ANR-14-CE09-0010-01).
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Communicated by M. Kupiec.
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Pagès, V. Single-strand gap repair involves both RecF and RecBCD pathways. Curr Genet 62, 519–521 (2016). https://doi.org/10.1007/s00294-016-0575-5
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DOI: https://doi.org/10.1007/s00294-016-0575-5