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Negative epistasis: a route to intraspecific reproductive isolation in yeast?

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Abstract

Exploring the molecular bases of intraspecific reproductive isolation captures the ongoing phenotypic consequences of genetic divergence and provides insights into the early onset of speciation. Recent species-wide surveys using natural populations of yeasts demonstrated that intrinsic post-zygotic reproductive isolation segregates readily within the same species, and revealed the multiplicity of the genetic mechanisms underlying such processes. These advances deepened our current understandings and opened further perspectives regarding the complete picture of molecular and evolutionary origins driving the onset of intraspecific reproductive isolation in yeasts.

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Acknowledgments

The authors thank the Agence Nationale de la Recherche (ANR Grant 2011-JSV6-004-01) and the National Institutes of Health (NIH Grant R01 GM101091-01) for financial support. J.H. is supported in part by a grant from the Ministère de l’Enseignement Supérieur et de la Recherche and in part by a fellowship from the La Ligue contre le Cancer.

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  1. Department of Genetics, Genomics and Microbiology, University of Strasbourg / CNRS, UMR7156, Strasbourg, France

    Jing Hou & Joseph Schacherer

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  1. Jing Hou
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  2. Joseph Schacherer
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Correspondence to Joseph Schacherer.

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Communicated by M. Kupiec.

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Hou, J., Schacherer, J. Negative epistasis: a route to intraspecific reproductive isolation in yeast?. Curr Genet 62, 25–29 (2016). https://doi.org/10.1007/s00294-015-0505-y

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