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Conjugated polymer-hybridized silica nanoparticle as a fluorescent sensor for cysteine

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Abstract

The detection of important biological thiols such as cysteine (Cys) is highly relevant to a variety of fundamental physiological processes in organisms. A conjugated polymer with pendant aldehyde group, which was used for reactive site for Cys, was synthesized via Suzuki coupling polymerization and the polymer was immobilized on the surface of amine-functionalized silica nanoparticles. The conjugated polymer-modified silica nanoparticles could be dispersed in alcoholic media, exhibiting various emission colors according to the alcoholic media, presumably due to the various polarity of the alcohols used. The organic–inorganic hybrid showed changes in emission color upon exposure to Cys with high selectivity over other amino acids, because of the specific reaction of aldehyde in the polymer and aminothiol group in Cys.

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Acknowledgments

Financial support from the National Research Foundation of Korea (NRF) funded by Korean Government through the Nuclear R&D Project (2015M2A7A1000217) is gratefully acknowledged.

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Authors and Affiliations

  1. Organic and Optoelectronic Materials Laboratory, Department of Organic Materials Engineering, Chungnam National University, Daejeon, 31434, Korea

    Geunseok Jang & Taek Seung Lee

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  1. Geunseok Jang
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  2. Taek Seung Lee
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Correspondence to Taek Seung Lee.

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Jang, G., Lee, T.S. Conjugated polymer-hybridized silica nanoparticle as a fluorescent sensor for cysteine. Polym. Bull. 73, 2447–2456 (2016). https://doi.org/10.1007/s00289-016-1672-9

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  • DOI: https://doi.org/10.1007/s00289-016-1672-9

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