Skip to main content

Advertisement

SpringerLink
Log in

An Epidemiologic Study on the Correlation Between Oral Helicobacter pylori and Gastric H. pylori

  • Published:
Current Microbiology Aims and scope Submit manuscript

Abstract

The current study was conducted to determine the prevalence of Helicobacter pylori in the oral cavity of a Chinese population. Nested polymerase chain reaction (PCR) was used to investigate whether individuals with oral H. pylori show more possibility of gastric infection and to examine the relationship between gastric H. pylori infection and the presence of the bacteria in the oral cavity. A total of 443 dyspeptic patients participated in the study. Gastric H. pylori infection was detected by the rapid urease test and histology with Giemsa staining, PCR, or smear examination, whereas the presence of the bacteria in the oral cavity was observed by nested PCR from dental plaque. Relevant periodontal and dental parameters were recorded in the process of oral examination. Of the 443 study patients, oral H. pylori was found in the dental plaque of 263 (59.4%) and the stomach of 273 (61.6%). Additionally, in all four age groups, the prevalence of gastric infection was significantly higher among the patients with positive tests for H. pylori in their dental plaque than in the patients with no H. pylori in their dental plaque (P < 0.05). The oral cavity may be a potential reservoir for H. pylori, and the prevalence of oral H. pylori approximated that of gastric H. pylori in the studied population. Furthermore, a close relationship may exist between H. pylori in the oral cavity and bacteria in the stomach or gastric infection, and dyspeptic patients with gastric infection are more likely to harbor H. pylori in their oral cavity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Berroteran A, Perrone M, Correnti M et al (2002) Detection of Helicobacter pylori DNA in the oral cavity and gastroduodenal system of a Venezuelan population. J Med Microbiol 51:764–770

    PubMed  CAS  Google Scholar 

  2. Bielański W (1999) Epidemiological study on Helicobacter pylori infection and extragastroduodenal disorders in Polish population. J Physiol Pharmacol 50:723–733

    PubMed  Google Scholar 

  3. Chitsazi MT, Fattahi E, Farahani RM, Fattahi S (2006) Helicobacter pylori in the dental plaque: is it of diagnostic value for gastric infection? Med Oral Patol Oral Cir Bucal 11:325–328

    Google Scholar 

  4. Czesnikiewicz-Guzik M, Bielanski W, Guzik TJ et al (2005) Helicobacter pylori in the oral cavity and its implications for gastric infection, periodontal health, immunology, and dyspepsia. J Physiol Pharmacol 56:77–89

    PubMed  Google Scholar 

  5. De Sousa L, Vásquez L, Velasco J, Parlapiano D (2006) Isolation of Helicobacter pylori in gastric mucosa, dental plaque, and saliva in a population from the Venezuelan Andes. Invest Clin 47:109–116

    PubMed  Google Scholar 

  6. Doré-Davin C, Heitz M, Yang H et al (1999) Helicobacter pylori in the oral cavity reflects handling of contaminants but not gastric infection. Digestion 60:196–202

    Article  PubMed  Google Scholar 

  7. Dowsett SA, Kowolik MJ (2003) Oral Helicobacter pylori: can we stomach it? Crit Rev Oral Biol Med 14:226–233

    Article  PubMed  CAS  Google Scholar 

  8. Dye BA, Kruszon-Moran D, McQuillan G (2002) The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States. Am J Public Health 92:1809–1815

    Article  PubMed  Google Scholar 

  9. Ferguson DA Jr, Li C, Patel NR et al (1993) Isolation of Helicobacter pylori from saliva. J Clin Microbiol 31:2802–2804

    PubMed  Google Scholar 

  10. Goodwin CS, Mendall MM, Northfield TC (1997) Helicobacter pylori infection. Lancet 349:265–269

    Article  PubMed  CAS  Google Scholar 

  11. Khandaker K, Palmer KR, Eastwood MA et al (1993) DNA fingerprints of Helicobacter pylori from mouth and antrum of patients with chronic ulcer dyspepsia (letter). Lancet 342:751

    Article  PubMed  CAS  Google Scholar 

  12. Li C, Musich PR, Ha T et al (1995) High prevalence of Helicobacter pylori in saliva demonstrated by a novel PCR assay. J Clin Pathol 48:662–666

    Article  PubMed  CAS  Google Scholar 

  13. Liu Y, Lin H, Bai Y et al (2008) Study on the relationship between Helicobacter pylori in the dental plaque and the occurrence of dental caries or oral hygiene index. Helicobacter 13:256–260

    Article  PubMed  CAS  Google Scholar 

  14. Mapstone NP, Lynch DA, Lewis FA et al (1993) Identification of Helicobacter pylori DNA in the mouths and stomachs of patients with gastritis using PCR. J Clin Pathol 46:540–543

    Article  PubMed  CAS  Google Scholar 

  15. Martinez-Gomis J, Diouf A, Lakhssassi N, Sixou M (2006) Absence of Helicobacter pylori in the oral cavity of 10 nondyspeptic subjects demonstrated by real-time polymerase chain reaction. Oral Microbiol Immunol 21:407–410

    Article  PubMed  CAS  Google Scholar 

  16. Nguyen AM, Engstrand L, Genta RM et al (1993) Detection of Helicobacter pylori in dental plaque by reverse transcription-polymerase chain reaction. J Clin Microbiol 31:783–787

    PubMed  CAS  Google Scholar 

  17. Oshowo A, Tunio M, Gillam D et al (1998) Oral colonization is unlikely to play an important role in Helicobacter pylori infection. Br J Surg 85:850–852

    Article  PubMed  CAS  Google Scholar 

  18. Parsonnet J, Shmuely H, Haggerty BS (1999) Fecal and oral shedding of Helicobacter pylori from healthy infected adults. J Am Med Assoc 282:2240–2245

    Article  CAS  Google Scholar 

  19. Sahin FI, Tinaz AC, Simşek IS et al (2001) Detection of Helicobacter pylori in dental plaque and gastric biopsy samples of Turkish patients by PCR-RFLP. Acta Gastroeneterol Belg 64:150–152

    CAS  Google Scholar 

  20. Song Q, Haller B, Schmid RM et al (1999) Helicobacter pylori in dental plaque: a comparison of different PCR primer sets. Dig Dis Sci 44:479–484

    Article  PubMed  CAS  Google Scholar 

  21. Song Q, Lange T, Spahr A et al (2000) Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR. J Med Microbiol 49:349–353

    PubMed  CAS  Google Scholar 

  22. Teoman I, Ozmeriç N, Ozcan G et al (2007) Comparison of different methods to detect Helicobacter pylori in the dental plaque of dyspeptic patients. Clin Oral Invest 11:201–205

    Article  Google Scholar 

  23. Urazova RZ, Shamsutdinov NSh, Kazantseva TIu (2001) Status of oral mucosa and periodontal tissue in children with gastroduodenal diseases associated with Helicobacter pylori. Stomatologiia (Mosk) 80:20–22

    CAS  Google Scholar 

  24. Wahlfors J, Meurman JH, Toskala J et al (1995) Development of a rapid PCR method for identification of Helicobacter pylori in dental plaque and gastric biopsy specimens. Eur J Clin Microbiol Infect Dis 14:780–786

    Article  PubMed  CAS  Google Scholar 

  25. Young KA, Allaker RP, Hardie JM (2001) Morphological analysis of Helicobacter pylori from gastric biopsies and dental plaque by scanning electron microscopy. Oral Microbiol Immunol 16:178–181

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Ying Liu, Aimin Li, Jide Wang, Bo Jiang, Yali Zhang & Yang Bai

  2. Department of Gastroenterology, The Second People’s Hospital of Guangdong Province, Guangzhou, 510515, China

    Hui Yue

Authors
  1. Ying Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hui Yue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aimin Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jide Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bo Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yali Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yang Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yang Bai.

Additional information

Y. Liu and H. Yue contributed equally to the accomplishment of this study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, Y., Yue, H., Li, A. et al. An Epidemiologic Study on the Correlation Between Oral Helicobacter pylori and Gastric H. pylori . Curr Microbiol 58, 449–453 (2009). https://doi.org/10.1007/s00284-008-9341-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00284-008-9341-3

Keywords

Search

Navigation