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Fluoroquinolone Resistance Linked to Both gyrA and parC Mutations in the Quinolone Resistance–Determining Region of Shigella dysenteriae Type 1

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Abstract

We examined the quinolone resistance–determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone-susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83 → Leu, Asp87 → Asn or Gly) and a single mutation (Ser80 → Ile) were detected in the QRDRs of gyrA and parC, respectively.

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Acknowledgments

This study was funded by the Japan Health Sciences Foundation under Cooperative Agreement No. GR-00309. The nucleotide sequences reported here were submitted in GenBank using NCBI Sequin, version 5.26, under accession numbers-AY692480-84, AY695829-32 for gyrA, AY776312-18 for gyrB, and AY776319-25 for parC.

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Authors and Affiliations

  1. ICDDR, B: Centre for Health and Population Research, GPO Box-128, Dhaka, 1000, Bangladesh

    Kaisar A. Talukder, Bijay K. Khajanchi, Mohammad A. Islam, Zhahirul Islam, Dilip K. Dutta, Mustafizur Rahman, Gopinath B. Nair & David A. Sack

  2. Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162, Japan

    Haruo Watanabe

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  1. Kaisar A. Talukder
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  2. Bijay K. Khajanchi
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  3. Mohammad A. Islam
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  4. Zhahirul Islam
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  5. Dilip K. Dutta
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  6. Mustafizur Rahman
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  7. Haruo Watanabe
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  8. Gopinath B. Nair
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  9. David A. Sack
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Correspondence to Kaisar A. Talukder.

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Talukder, K.A., Khajanchi, B.K., Islam, M.A. et al. Fluoroquinolone Resistance Linked to Both gyrA and parC Mutations in the Quinolone Resistance–Determining Region of Shigella dysenteriae Type 1. Curr Microbiol 52, 108–111 (2006). https://doi.org/10.1007/s00284-005-0140-9

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  • DOI: https://doi.org/10.1007/s00284-005-0140-9

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