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Pathogenic CD8+ T cells in experimental cerebral malaria

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Abstract

Cerebral malaria (CM) is one the major complications occurring during malaria infection. The mechanisms leading to this syndrome are still not completely understood. Although it is clear that parasite sequestration is the key initiation factor, the downstream pathological processes are still highly debated. The experimental cerebral malaria (ECM) model, in which susceptible mice are infected with Plasmodium berghei ANKA, has led to the identification of CD8+ T cells as the major mediator of ECM death. In this review, we discuss the recent advances and future developments in the understanding of the role of CD8+ T cells in CM.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Shanshan Wu Howland, Carla Claser, Chek Meng Poh, Sin Yee Gun & Laurent Rénia

  2. Department of Microbiology, Life Sciences Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Chek Meng Poh, Sin Yee Gun & Laurent Rénia

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  1. Shanshan Wu Howland
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  2. Carla Claser
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  3. Chek Meng Poh
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  4. Sin Yee Gun
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  5. Laurent Rénia
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Correspondence to Laurent Rénia.

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This article is a contribution to the Special Issue on : CD8+ T-cell Responses against Non-viral Pathogens - Guest Editors: Fidel Zavala and Imtiaz Khan

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Howland, S.W., Claser, C., Poh, C.M. et al. Pathogenic CD8+ T cells in experimental cerebral malaria. Semin Immunopathol 37, 221–231 (2015). https://doi.org/10.1007/s00281-015-0476-6

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  • DOI: https://doi.org/10.1007/s00281-015-0476-6

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