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Update on crescentic glomerulonephritis

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Abstract

The recent years have seen a number of major progresses in the field of extracapillary glomerulonephritis. This entity is the final damage caused by unrelated immunological disorders such as immune complexes glomerular deposits or microvascular injury caused by proinflammatory cytokines, neutrophil extracellular traps (NET), and cell adhesion molecules in the context of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This review provides a summary of recent advances in the understanding of crescentic glomerulonephritis, focusing on interplays of local immune cells and on local mediators participating to crescent formation especially in anti-glomerular basement membrane (anti-GBM) antibody disease. The recent advances about AAV and lupus nephritis are covered by other chapters of this issue. Nevertheless, these considerations may apply to the general case of crescentic glomerulonephritis of all causes.

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Acknowledgments

We apologize to those authors whose important publications could not be quoted in this review owing to space limitations. We thank Pr. Pierre Ronco for critical and useful suggestions.

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Authors and Affiliations

  1. Paris Cardiovascular Centre - PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France

    Carole Hénique, Christina Papista, Léa Guyonnet, Olivia Lenoir & Pierre-Louis Tharaux

  2. Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Carole Hénique, Christina Papista, Léa Guyonnet, Olivia Lenoir & Pierre-Louis Tharaux

  3. Service de Néphrologie, Hôpital Européen Georges Pompidou, Assistance Publique–Hôpitaux de Paris, Paris, France

    Pierre-Louis Tharaux

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  1. Carole Hénique
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  2. Christina Papista
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  3. Léa Guyonnet
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  4. Olivia Lenoir
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  5. Pierre-Louis Tharaux
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Correspondence to Pierre-Louis Tharaux.

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This article is a contribution to the special issue on Immunopathology of Glomerular Diseases - Guest Editors: P. Ronco and J. Floege

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Hénique, C., Papista, C., Guyonnet, L. et al. Update on crescentic glomerulonephritis. Semin Immunopathol 36, 479–490 (2014). https://doi.org/10.1007/s00281-014-0435-7

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