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Th2 responses in schistosomiasis

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Abstract

Schistosomiasis is caused by infection with parasitic flatworms of the genus Schistosoma. It is characterized by the development of strong CD4+ T cell and B cell responses that, during primary infection, fail to eliminate the parasites, but in collaboration with cells of the innate immune system allow survival in the face of ongoing tissue damage caused by the lodging of parasite eggs in the liver and the passage of eggs across the intestinal epithelium. Mounting a tightly controlled Th2 response is key to this outcome, and while this type of response is a risk factor for the development of fibrosis, it also underpins the development of resistance to further infection; as such, understanding how Th2 responses are induced and regulated in schistosomiasis remains a critical area of research.

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Acknowledgment

Work in the Pearce laboratory is supported by the NIH (to EJP) and by Merck-UNCF to KF.

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Authors and Affiliations

  1. Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Keke Fairfax, Marcia Nascimento, Stanley Ching-Cheng Huang, Bart Everts & Edward J. Pearce

  2. Room 8126, BJCIH, 660 South Euclid Avenue, Campus Box 8118, St. Louis, MO, 63110, USA

    Edward J. Pearce

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  1. Keke Fairfax
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  2. Marcia Nascimento
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  3. Stanley Ching-Cheng Huang
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  4. Bart Everts
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Correspondence to Edward J. Pearce.

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This article is a contribution to the Special Issue on Immunoparasitology - Guest Editor: Miguel Stadecker

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Fairfax, K., Nascimento, M., Huang, S.CC. et al. Th2 responses in schistosomiasis. Semin Immunopathol 34, 863–871 (2012). https://doi.org/10.1007/s00281-012-0354-4

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  • DOI: https://doi.org/10.1007/s00281-012-0354-4

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