Skip to main content
SpringerLink
Log in

Successful treatment of systemic mastocytosis with acute myeloid leukemia: a case report

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Data availability

The original contributions presented in the study are included in the article. Further inquiries can be directed to the corresponding author.

References

  1. Arock M, Sotlar K, Akin C, Broesby-Olsen S, Hoermann G, Escribano L, Kristensen TK, Kluin-Nelemans HC, Hermine O, Dubreuil P, Sperr WR, Hartmann K, Gotlib J, Cross NC, Haferlach T, Garcia-Montero A, Orfao A, Schwaab J, Triggiani M et al (2015) KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis. Leukemia 29(6):1223–1232. https://doi.org/10.1038/leu.2015.24

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Schnittger S, Kohl TM, Haferlach T, Kern W, Hiddemann W, Spiekermann K, Schoch C (2006) KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival. Blood 107(5):1791–1799. https://doi.org/10.1182/blood-2005-04-1466

    Article  CAS  PubMed  Google Scholar 

  3. Lim KH, Tefferi A, Lasho TL, Finke C, Patnaik M, Butterfield JH, McClure RF, Li CY, Pardanani A (2009) Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood 113(23):5727–5736. https://doi.org/10.1182/blood-2009-02-205237

    Article  CAS  PubMed  Google Scholar 

  4. Pullarkat ST, Pullarkat V, Kroft SH, Wilson CS, Ahsanuddin AN, Mann KP, Thein M, Grody WW, Brynes RK (2009) Systemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemia. J Hematop 2(1):27–33. https://doi.org/10.1007/s12308-009-0023-2

    Article  PubMed  PubMed Central  Google Scholar 

  5. Xie W, Wang SA, Yin CC, Xu J, Li S, Bueso-Ramos CE, Medeiros LJ, Tang G (2019) Acute myeloid leukemia with t(8;21)(q22;q22.1)/RUNX1-RUNX1T1 and KIT Exon 8 mutation is associated with characteristic mastocytosis and dismal outcomes. Exp Mol Pathol 108:131–136. https://doi.org/10.1016/j.yexmp.2019.04.009

    Article  CAS  PubMed  Google Scholar 

  6. Nagai S, Ichikawa M, Takahashi T, Sato H, Yokota H, Oshima K, Izutsu K, Hangaishi A, Kanda Y, Motokura T, Chiba S, Yatomi Y, Kurokawa M (2007) The origin of neoplastic mast cells in systemic mastocytosis with AML1/ETO-positive acute myeloid leukemia. Exp Hematol 35(11):1747–1752. https://doi.org/10.1016/j.exphem.2007.08.016

    Article  CAS  PubMed  Google Scholar 

  7. Valent P, Akin C, Hartmann K, Reiter A, Gotlib J, Sotlar K, Sperr WR, Degenfeld-Schonburg L, Smiljkovic D, Triggiani M, Horny HP, Arock M, Galli SJ, Metcalfe DD (2022) Drug-induced mast cell eradication: a novel approach to treat mast cell activation disorders? J Allergy Clin Immunol 149(6):1866–1874. https://doi.org/10.1016/j.jaci.2022.04.003

    Article  CAS  PubMed  Google Scholar 

  8. Lubke J, Naumann N, Kluger S, Schwaab J, Metzgeroth G, Evans E, Gardino AK, Lengauer C, Hofmann WK, Fabarius A, Cross NCP, Reiter A, Jawhar M (2019) Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis. Leukemia 33(5):1195–1205. https://doi.org/10.1038/s41375-019-0450-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. DeAngelo DJ, Radia DH, George TI, Robinson WA, Quiery AT, Drummond MW, Bose P, Hexner EO, Winton EF, Horny HP, Tugnait M, Schmidt-Kittler O, Evans EK, Lin HM, Mar BG, Verstovsek S, Deininger MW, Gotlib J (2021) Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial. Nat Med 27(12):2183–2191. https://doi.org/10.1038/s41591-021-01538-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Reiter A, Schwaab J, DeAngelo DJ, Gotlib J, Deininger MW, Pettit KM, Alvarez-Twose I, Vannucchi AM, Panse J, Platzbecker U, Hermine O, Dybedal I, Lin HM, Rylova SN, Ehlert K, Dimitrijevic S, Radia DH (2022) Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosis. Blood Adv 6(21):5750–5762. https://doi.org/10.1182/bloodadvances.2022007539

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank the patient for allowing us to report his case and acknowledged the support of nurses and laboratory scientists who had participated in the process of diagnosis and treatment.

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 82070164).

Author information

Author notes

  1. Minran Zhou and Guangcai Zhong contributed equally to this work and share first authorship.

Authors and Affiliations

  1. Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, China

    Minran Zhou, Guangcai Zhong, Yuan Yu, Ran Wang, Sai Ma & Chunyan Chen

Authors
  1. Minran Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Guangcai Zhong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuan Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ran Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sai Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chunyan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

GZ and MZ contributed equally to this work. GZ wrote the manuscript and analyzed the data. MZ collected and analyzed the data. YY, RW and SM manage the patient treatment throughout the process. CC supervised the study. All authors approved the submitted version of the paper.

Corresponding author

Correspondence to Chunyan Chen.

Ethics declarations

Ethics approval

Written informed consent was obtained from the patient for the publication of any potentially identifiable images or data included in this article.

Conflict of interest

The authors declare no competing interests.

Disclosure

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, M., Zhong, G., Yu, Y. et al. Successful treatment of systemic mastocytosis with acute myeloid leukemia: a case report. Ann Hematol 102, 2951–2953 (2023). https://doi.org/10.1007/s00277-023-05341-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-023-05341-z

Search

Navigation