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Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era

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Abstract

Immunoglobulin D (IgD) myeloma is a rare subtype that used to lead to a poor outcome. To investigate the current clinical features, cytogenetic changes and survival of patients with IgD myeloma under novel treatments, we analysed 47 patients with IgD myeloma, 31 men and 16 women, with a median age of 54.5 years. We found that IgD myeloma was associated with higher frequencies of anaemia, renal failure, and hypercalcemia and higher levels of serum LDH compared with non-IgD myeloma. More than 90% of patients with IgD myeloma had at least one cytogenetic abnormality demonstrated by fluorescence in situ hybridisation (FISH). IGH translocations were the most common abnormalities, which were mainly caused by t(11;14). Moreover, 36.2% of patients were at the Revised International Staging System (RISS) stage III when diagnosed. Those patients had significantly shorter PFS and OS compared with patients at RISS stages I and II. In conclusion, IgD myeloma has specific clinical characteristics. The RISS grade was shown to be a simple and effective method to predict the prognosis of patients with IgD myeloma.

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Funding

This study was funded by the National Natural Science Foundation of China under grant no. 81272625 and no. 81670197 for Chunyan Sun.

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Authors and Affiliations

  1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan, 430022, China

    Lei Chen, Fengjuan Fan, Jun Deng, Jian Xu, Aoshuang Xu, Chunyan Sun & Yu Hu

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  1. Lei Chen
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  2. Fengjuan Fan
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  4. Jian Xu
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Correspondence to Chunyan Sun or Yu Hu.

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Chen, L., Fan, F., Deng, J. et al. Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era. Ann Hematol 98, 963–970 (2019). https://doi.org/10.1007/s00277-018-3582-4

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