Skip to main content
SpringerLink
Log in

Conversion from nuclear bilobation to indentation in BCR/ABL1-positive acute myeloid leukemia lacking CD34 and HLA-DR expression

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Kussick SJ, Stirewalt DL, Yi HS, Sheets KM, Pogosova-Agadjanyan E, Braswell S, Norwood TH, Radich JP, Wood BL (2004) A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication. Leukemia 18:1591–1598

  2. Chen W, Konoplev S, Medeiros LJ, Koeppen H, Leventaki V, Vadhan-Raj S, Jones D, Kantarjian HM, Falini B, Bueso-Ramos CE (2009) Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation. Cancer 115:5481–5489

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Carluccio P, Mestice A, Pastore D, Delia M, Ricco A, Russo-Rossi A, Casieri P, Liso A, Martelli MP, Albano F, Specchia G (2014) Immunophenotypic and molecular features of ‘cuplike’ acute myeloid leukemias. Eur J Haematol 92:121–126

    Article  CAS  PubMed  Google Scholar 

  4. Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF, GIMEMA Acute Leukemia Working Party (2005) Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 352:254–266

    Article  CAS  PubMed  Google Scholar 

  5. Andersen MT, Andersen MK, Christiansen DH, Pedersen-Bjergaard J (2008) NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic features. Leukemia 22:951–955

    Article  CAS  PubMed  Google Scholar 

  6. Arber DA, Brunning RD, Le Beau MM, Falini B, Vardiman JW, Porwit A, Thiele J, Bloomfield CD (2008) Acute promyelocytic leukaemia with t(15;17)(q22;q12); PML-RARA. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) WHO classification of tumors of haematopoietic and lymphoid tissues, 4th edn. International Agency for Research on Cancer, Lyon, pp 112–114

    Google Scholar 

  7. Nagendra S, Meyerson H, Skallerud G, Rosenthal N (2002) Leukemias resembling acute promyelocytic leukemia, microgranular variant. Am J Clin Pathol 117:651–657

    Article  PubMed  Google Scholar 

  8. Sakai H, Sato K, Tsuruoka Y, Kato M, Takahashi T, Miura I (2013) Acute myeloid leukaemia with cup-like nuclei associated with t(9;22)(q34;q11.2). Br J Haematol 162:145

    Article  PubMed  Google Scholar 

  9. Konoplev S, Yin CC, Kornblau SM, Kantarjian HM, Konopleva M, Andreeff M, Lu G, Zuo Z, Luthra R, Medeiros LJ, Bueso-Ramos CE (2013) Molecular characterization of de novo philadelphia chromosome-positive acute myeloid leukemia. Leuk Lymphoma 54:138–144

  10. Fujisawa S, Kanamori H, Takabayashi M, Tanaka M, Yamaji S, Tomita N, Fujimaki K, Ishigatsubo Y (2002) Acute lymphoblastic leukemia with t(1;9;22)(q32;q34;q11). Int J Hematol 75:443–445

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Katsuya Yamamoto, Kimikazu Yakushijin, Yukinari Sanada, Shinichiro Kawamoto, Hiroshi Matsuoka & Hironobu Minami

  2. Division of Clinical Laboratory, Kobe University Hospital, Kobe, Japan

    Yuji Nakamachi & Seiji Kawano

Authors
  1. Katsuya Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kimikazu Yakushijin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukinari Sanada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinichiro Kawamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuji Nakamachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Seiji Kawano
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hiroshi Matsuoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hironobu Minami
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Katsuya Yamamoto.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yamamoto, K., Yakushijin, K., Sanada, Y. et al. Conversion from nuclear bilobation to indentation in BCR/ABL1-positive acute myeloid leukemia lacking CD34 and HLA-DR expression. Ann Hematol 94, 177–179 (2015). https://doi.org/10.1007/s00277-014-2133-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-014-2133-x

Keywords

Search

Navigation