Skip to main content

Advertisement

SpringerLink
Log in

Complete cytogenetic remission after decitabine treatment in a patient with secondary AML harbouring high p15 INK4b gene methylation and high global DNA methylation

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Boultwood J, Wainscoat JS (2007) Gene silencing by DNA methylation in haematological malignancies. Br J Haematol 138:3–11 doi:10.1111/j.1365-2141.2007.06604.x

    Article  PubMed  CAS  Google Scholar 

  2. Griffiths EA, Gore SD (2008) DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol 45:23–30 doi:10.1053/j.seminhematol.2007.11.007

    Article  PubMed  CAS  Google Scholar 

  3. Raj K, John A, Ho A, Chronis C, Khan S, Samuel J et al (2007) CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 21:1937–1944 doi:10.1038/sj.leu.2404796

    Article  PubMed  CAS  Google Scholar 

  4. Brakensiek K, Wingen LU, Langer F, Kreipe H, Lehmann U (2007) Quantitative high-resolution CpG Island Mapping with Pyrosequencing™ reveals disease-specific methylation patterns of the CDKN2B gene in myelodysplastic syndrome and myeloid leukemia. Clin Chem 53:17–23 doi:10.1373/clinchem.2007.072629

    Article  PubMed  CAS  Google Scholar 

  5. Tessema M, Langer F, Dingemann J, Ganser A, Kreipe H, Lehmann U (2003) Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). Leukemia 17:910–918 doi:10.1038/sj.leu.2402891

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by a grant from the Deutsche Krebshilfe, Dr. Mildred Scheel Stiftung (to UL and HK).

Author information

Authors and Affiliations

  1. Institute of Pathology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625, Hannover, Germany

    Ulrich Lehmann, Daniel Römermann, Britta Hasemeier, Kathleen Metzig, Guntram Büsche & Hans Kreipe

  2. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, Germany

    Christiane Dobbelstein, Martin Fenner, Jürgen Krauter & Arnold Ganser

  3. Institute of Cell and Molecular Pathology, Medizinische Hochschule Hannover, Hannover, Germany

    Doris Steinemann

Authors
  1. Ulrich Lehmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christiane Dobbelstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martin Fenner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel Römermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Britta Hasemeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kathleen Metzig
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Doris Steinemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Guntram Büsche
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jürgen Krauter
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Arnold Ganser
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Hans Kreipe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ulrich Lehmann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lehmann, U., Dobbelstein, C., Fenner, M. et al. Complete cytogenetic remission after decitabine treatment in a patient with secondary AML harbouring high p15 INK4b gene methylation and high global DNA methylation. Ann Hematol 88, 275–277 (2009). https://doi.org/10.1007/s00277-008-0584-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-008-0584-7

Keywords

Search

Navigation