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Epigenetic regulation of tumor suppressors in t(8:21)-containing AML

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Abstract

The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.

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Authors and Affiliations

  1. Department of Biochemistry, Vanderbilt University School of Medicine, PRB 512, 23rd and Pierce, Nashville, Tennessee, 37232, USA

    Genyan Yang & Scott W. Hiebert

  2. Departments of Microbiology, Immunology and Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN, USA

    Waleed Khalaf & D. Wade Clapp

  3. Department of Hematology, University Medical Center St. Radboud, Nijmegen, The Netherlands

    Louis van de Locht, Joop H. Jansen & Bert A. van der Reijden

  4. Department of Medicine, Hematology and Oncology, University of Münster, Münster, Germany

    Carsten Müller-Tidow & Hubert Serve

  5. Department of Hematology, Erasmus University, Rotterdam, The Netherlands

    H. Ruud Delwel

  6. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    Scott W. Hiebert

Authors
  1. Genyan Yang
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  2. Waleed Khalaf
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  3. Louis van de Locht
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  4. Joop H. Jansen
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  5. Bert A. van der Reijden
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  6. Carsten Müller-Tidow
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  7. H. Ruud Delwel
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  8. Hubert Serve
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  9. D. Wade Clapp
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  10. Scott W. Hiebert
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Corresponding author

Correspondence to Scott W. Hiebert.

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Yang, G., Khalaf, W., van de Locht, L. et al. Epigenetic regulation of tumor suppressors in t(8:21)-containing AML. Ann Hematol 83, 329–330 (2004). https://doi.org/10.1007/s00277-003-0841-8

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  • DOI: https://doi.org/10.1007/s00277-003-0841-8

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