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Small Intestinal Submucosa Plug for Closure of Dilated Nephrostomy Tracts: A Pilot Study in Swine

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Abstract

The aim of this study was to evaluate efficacy of a plug made of small intestinal submucosa (SIS) for closure of dilated nephrostomy tract in the kidney after nephroscopy. Ten kidneys in 5 swine had nephrostomy tracts dilated up to 8 mm. The SIS plug was placed into the dilated renal cortex under nephroscopic control. Follow-up arteriograms, retrograde pyelograms, and macroscopic and histologic studies at 24 h (n = 4), 6 weeks (n = 2), and 3 months (n = 4) were performed to evaluate the efficacy of the plug. The SIS plug effectively closed the dilated nephrostomy tract. Follow-up studies showed minimal changes of the kidneys, except for 1 small infarction, regarding inflammatory and foreign-body reactions and progressive scarring of the SIS. SIS plug is effective for occlusion of dilated nephrostomy tract after nephroscopy. Its efficacy should be compared with other therapeutic options.

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Authors and Affiliations

  1. Dotter Interventional Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L-342, Portland, OR, 97239-3098, USA

    Hideyaki Kakizawa, Dusan Pavcnik, Barry T. Uchida, Young Hwan Kim, Frederick S. Keller & Josef Rösch

  2. Division of Urology, Department of Surgery, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L-342, Portland, OR, 97239-3098, USA

    M. J. Conlin

  3. Department of Pathology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L-342, Portland, OR, 97239-3098, USA

    Marc Loriaux

Authors
  1. Hideyaki Kakizawa
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  2. M. J. Conlin
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  3. Dusan Pavcnik
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  4. Barry T. Uchida
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  5. Marc Loriaux
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  6. Young Hwan Kim
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  7. Frederick S. Keller
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  8. Josef Rösch
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Correspondence to Dusan Pavcnik.

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Kakizawa, H., Conlin, M.J., Pavcnik, D. et al. Small Intestinal Submucosa Plug for Closure of Dilated Nephrostomy Tracts: A Pilot Study in Swine. Cardiovasc Intervent Radiol 33, 596–600 (2010). https://doi.org/10.1007/s00270-010-9811-4

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  • DOI: https://doi.org/10.1007/s00270-010-9811-4

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