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Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler

  • Original Article
  • Basic Science/Experimental
  • Published:
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Abstract

Objective

To evaluate the efficacy and safety of an injectable lyophilized articular cartilage matrix (LACM) which is in the form of cartilage powder that may increase the convenience of use and become unaffected by donor site morbidity as a potential filler.

Methods

The safety test was conducted using 20 rabbits with an intravascular embolization model. Commonly used commercial hyaluronic acid (HA), acellular dermal matrix (ADM), polymethyl methacrylate (PMMA), and polylactic acid (PLA) products were selected for comparison of efficacy and adverse effect of LACM. The efficacy test was performed using 30 mice subcutaneous buttock-injection model. Gross assessments of the changes in size of injected materials and histological examinations were conducted.

Results

Regarding the safety test, in one rabbit in the HA group, complete blurring occurred in the left eye, and necrosis of the posterior auricular artery was observed in one rabbit in the ADM group. In the ADM, severe ecchymosis around the injection sites was observed, and the bruises lasted longer than in the other groups. The LACM exhibited faster bruise resolution. Comparing the changes in size between weeks 4 and 12 in the mouse model, no significant changes in size were observed in the LACM (p = 0.359), HA (p = 0.421), and ADM (p = 0.097), but a significant change was observed in the PMMA (p = 0.001). In the histological examination, LACM exhibited well-demarcated margins with good biocompatibility.

Conclusion

The LACM shows potential as a facial filler according to the in vivo safety and efficacy tests

Level of Evidence V

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Author notes

  1. Se Hwan Hwang and Do Hyun Kim the first two authors contributed equally to this paper.

Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Se Hwan Hwang

  2. Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul, 06591, Republic of Korea

    Do Hyun Kim & Soo Whan Kim

  3. ROKIT Healthcare, Inc., Seoul, Korea

    Bo Mi Nam & Ji Yeon Mun

  4. Department of Otolaryngology-Head and Neck Surgery, GNG hospital, Seoul, Korea

    Yong Hae Seong

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  1. Se Hwan Hwang
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Correspondence to Soo Whan Kim.

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The authors declare that they have no conflict of interest.

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All applicable institutional and/or national guidelines for the care and use of animals were followed.

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Hwang, S.H., Kim, D.H., Nam, B.M. et al. Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler. Aesth Plast Surg 45, 1266–1272 (2021). https://doi.org/10.1007/s00266-020-02017-1

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  • DOI: https://doi.org/10.1007/s00266-020-02017-1

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