Abstract
Objective
This study aimed to analyze the clinical factors related to the failure of autologous bone marrow mononuclear cells grafting (BMMCG) following core decompression (CD) in early stage osteonecrosis of the femoral head (ONFH).
Methods
In total, 148 patients (192 hips) underwent CD with autologous BMMCG for treatment of non-traumatic ONFH. The patients were classified by their ARCO staging and China-Japan Friendship Hospital (CJFH) typing system. All patients were clinically and radiographically followed up every three months during the first year and every six months in the following years. The clinical evaluation was conducted by pre- and post-operative Harris hip scores (HHS), while serial anteroposterior (AP) and frog lateral radiographs were used for post-operative radiographic evaluation.
Results
There were 56 hips as clinical failure cases, and 50 hips (89.29%) of failure cases developed between three and ten months after operation. Based on CJFH classification system, type L2 showed more failure rate with 60.0% (9 of15). The Cox risk model showed that disease type was an independent risk factor for post-operative clinical failure (P = 0.042). Multivariate analysis of the Cox proportional-hazards model showed that type L1 had a hazard ratio (HR) of 0.286 (95% CI 0.100–0.816), type L3 with HR of 0.245 (95% CI 0.079–0.759), respectively.
Conclusion
Disease type is an important risk factor for autologous BMMCG combined with CD, and the degree of lateral pillar necrosis is a significant reference index for prognosis evaluation in early stage of ONFH.
Similar content being viewed by others
References
Mont MA, Zywiel MG, Marker DR, McGrath MS, Delanois RE (2010) The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review. J Bone Joint Surg Am 92(12):2165–2170. https://doi.org/10.2106/JBJS.I.00575
Lieberman JR, Engstrom SM, Meneghini RM, SooHoo NF (2012) Which factors influence preservation of the osteonecrotic femoral head? Clin Orthop Relat Res 470(2):525–534. https://doi.org/10.1007/s11999-011-2050-4
Tomaru Y, Yoshioka T, Sugaya H, Aoto K, Wada H, Akaogi H et al (2017) Hip preserving surgery with concentrated autologous bone marrow aspirate transplantation for the treatment of asymptomatic osteonecrosis of the femoral head: retrospective review of clinical and radiological outcomes at 6 years postoperatively. BMC Musculoskelet Disord 18(1):292. https://doi.org/10.1186/s12891-017-1652-8
Ficat P, Arlet J, Vidal R, Ricci A, Fournial JC (1971) Therapeutic results of drill biopsy in primary osteonecrosis of the femoral head (100 cases). Rev Rhum Mal Osteoartic 38(4):269–276
Al OA (2013) Multiple drilling compared with standard core decompression for avascular necrosis of the femoral head in sickle cell disease patients. Arch Orthop Trauma Surg 133(5):609–613. https://doi.org/10.1007/s00402-013-1714-9
Hernigou P, Beaujean F (2002) Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 405:14–23
Hernigou P, Poignard A, Zilber S, Rouard H (2009) Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop 43(1):40–45. https://doi.org/10.4103/0019-5413.45322
Wang BL, Sun W, Shi ZC, Zhang NF, Yue DB, Guo WS et al (2010) Treatment of nontraumatic osteonecrosis of the femoral head with the implantation of core decompression and concentrated autologous bone marrow containing mononuclear cells. Arch Orthop Trauma Surg 130(7):859–865. https://doi.org/10.1007/s00402-009-0939-0
Sen RK, Tripathy SK, Aggarwal S, Marwaha N, Sharma RR, Khandelwal N (2012) Early results of core decompression and autologous bone marrow mononuclear cells instillation in femoral head osteonecrosis: a randomized control study. J Arthroplasty 27(5):679–686. https://doi.org/10.1016/j.arth.2011.08.008
Beckmann J, Schmidt T, Schaumburger J, Rath B, Luring C, Tingart M et al (2013) Infusion, core decompression, or infusion following core decompression in the treatment of bone edema syndrome and early avascular osteonecrosis of the femoral head. Rheumatol Int 33(6):1561–1565. https://doi.org/10.1007/s00296-012-2597-8
Hernigou P, Trousselier M, Roubineau F, Bouthors C, Chevallier N, Rouard H et al (2016) Stem cell therapy for the treatment of hip osteonecrosis: a 30-year review of progress. Clin Orthop Surg 8(1):1–8. https://doi.org/10.4055/cios.2016.8.1.1
Houdek MT, Wyles CC, Packard BD, Terzic A, Behfar A, Sierra RJ (2016) Decreased osteogenic activity of mesenchymal stem cells in patients with corticosteroid-induced osteonecrosis of the femoral head. J Arthroplast 31(4):893–898. https://doi.org/10.1016/j.arth.2015.08.017
Piuzzi NS, Chahla J, Schrock JB, LaPrade RF, Pascual-Garrido C, Mont MA et al (2017) Evidence for the use of cell-based therapy for the treatment of osteonecrosis of the femoral head: a systematic review of the literature. J Arthroplast 32(5):1698–1708. https://doi.org/10.1016/j.arth.2016.12.049
Sun W, Li ZR, Gao FQ, Shi ZC, Wang BL, Guo WS (2014) Porous bioceramic beta-tricalcium phosphate for treatment of osteonecrosis of the femoral head. Zhongguo Zuzhi Gongcheng Yanjiu 16:2474–2479. https://doi.org/10.3969/j.issn.2095-4344.2014.16.003
Hernigou P, Flouzat-Lachaniette CH, Delambre J, Poignard A, Allain J, Chevallier N et al (2015) Osteonecrosis repair with bone marrow cell therapies: state of the clinical art. Bone 70:102–109. https://doi.org/10.1016/j.bone.2014.04.034
Piuzzi NS, Chahla J, Jiandong H, Chughtai M, LaPrade RF, Mont MA et al (2017) Analysis of cell therapies used in clinical trials for the treatment of osteonecrosis of the femoral head: a systematic review of the literature. J Arthroplast. https://doi.org/10.1016/j.arth.2017.02.075
Hernigou P, Beaujean F, Lambotte JC (1999) Decrease in the mesenchymal stem-cell pool in the proximal femur in corticosteroid-induced osteonecrosis. J Bone Joint Surg Br 81(2):349–355
Wang BL, Li TJ, Yue DB, Sun W (2014) Proliferation ability of bone marrow mesenchymal stem cells in corticosteroid-induced osteonecrosis of femoral head. Zhongguo Zuzhi Gongcheng Yanjiu 1:7–13. https://doi.org/10.3969/j.issn.2095-4344.2014.01.002
Gangji V, De Maertelaer V, Hauzeur JP (2011) Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: five year follow-up of a prospective controlled study. Bone 49(5):1005–1009. https://doi.org/10.1016/j.bone.2011.07.032
Maus U, Roth A, Tingart M, Rader C, Jager M, Noth U et al (2015) S3 guideline. Part 3: non-traumatic avascular necrosis in adults—surgical treatment of atraumatic avascular femoral head necrosis in adults. Z Orthop Unfall 153(5):498–507. https://doi.org/10.1055/s-0035-1545902
Sun W, Li ZR, Wang BL, Liu BL, Zhang QD, Guo WS (2014) Relationship between preservation of the lateral pillar and collapse of the femoral head in patients with osteonecrosis. Orthopedics 37(1):e24–e28
Bozic KJ, Zurakowski D, Thornhill TS (1999) Survivorship analysis of hips treated with core decompression for nontraumatic osteonecrosis of the femoral head. J Bone Joint Surg Am 81(2):200–209
Funding
This study was supported by the National Natural Science Foundation of China (81672236, 81372013), and Beijing Natural Science Foundation (7182146).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
The procedures performed in this study involving human participants were approved by the ethics committee of China-Japan Friendship Hospital. (File 1)
Informed consent
Informed consent was obtained from all individual participants included in the study. (File 2)
Rights and permissions
About this article
Cite this article
Liu, L., Gao, F., Sun, W. et al. Investigating clinical failure of core decompression with autologous bone marrow mononuclear cells grafting for the treatment of non-traumatic osteonecrosis of the femoral head. International Orthopaedics (SICOT) 42, 1575–1583 (2018). https://doi.org/10.1007/s00264-018-3918-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00264-018-3918-7