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Biphasic bone substitute and fibrin sealant for treatment of benign bone tumours and tumour-like lesions

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Abstract

Purpose

Bone defects resulting from tumour resection or curettage are most commonly reconstructed with autologous bone graft which is associated with limited availability and donor site morbidity. Recent research has focussed on synthetic biomaterials as bone graft substitutes. The aim of this study was to assess the safety and efficiency of a bone substitute as an alternative for autologous bone in the treatment of benign bone tumours and tumour-like lesions.

Methods

In the present study, a biphasic ceramic (60% HA and 40% β-TCP) combined with a fibrin sealant was used to reconstruct defects in 51 patients after curettage of benign bone tumours or tumour-like lesions. Patient age ranged from eight to 68 years (mean 29.7), defect size from 2 cm3 to 35 cm3 (mean 12.1), and time of follow-up from one to 56 months (mean 22.7).

Results

Radiologic analysis showed complete bony defect consolidation in 50 of 51 patients after up to 56 months. No postoperative fractures were observed. Revision surgery had to be performed in one case. Histological analysis showed new bone formation and good biocompatibility and osseointegration of the implanted material.

Conclusion

In summary, the biphasic ceramic in combination with fibrin sealant was proven an effective alternative to autologous bone grafts eliminating the risk of donor site morbidity for the patient.

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Acknowledgments

The authors would like to acknowledge Maurice Bagot d’Arc, Baxter BioSciences for his advice and support and for critically proof reading the manuscript.

Conflict of interest

The applied biomaterial was sponsored by Baxter BioScience, Vienna, Austria. There are no financial relationships with Baxter BioScience and the authors. The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Orthopaedic Center for Musculoskeletal Research, König-Ludwig-Haus, Julius-Maximilians-University Würzburg, Brettreichstrasse 11, 97074, Würzburg, Germany

    Stephan Reppenhagen, Johannes C. Reichert, Lars Rackwitz, Maximilian Rudert, Peter Raab & Ulrich Nöth

  2. INSERM CIC-IT Biomaterials, CHU Bordeaux, Hôpital Xavier Arnozan, Bordeaux, France

    Guy Daculsi

Authors
  1. Stephan Reppenhagen
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  2. Johannes C. Reichert
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  3. Lars Rackwitz
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  4. Maximilian Rudert
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  5. Peter Raab
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  6. Guy Daculsi
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  7. Ulrich Nöth
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Corresponding author

Correspondence to Ulrich Nöth.

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Reppenhagen, S., Reichert, J.C., Rackwitz, L. et al. Biphasic bone substitute and fibrin sealant for treatment of benign bone tumours and tumour-like lesions. International Orthopaedics (SICOT) 36, 139–148 (2012). https://doi.org/10.1007/s00264-011-1282-y

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  • DOI: https://doi.org/10.1007/s00264-011-1282-y

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