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Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance

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Abstract

Expression of monocyte chemoattractant protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) and its significance has been demonstrated in some cancer cells in recent clinical studies. However, the role of tumor MCP-1 and CCR2 expression in non-small cell lung cancer (NSCLC) remains unknown. The aim of the present study was to investigate the prognostic significance of MCP-1 and CCR2 expression in NSCLC cells. The relationship between MCP-1 and CCR2 expression in NSCLC cancer cells was examined by immunohistochemical staining of surgical specimens from 134 patients. Sixty-five of these patients had follow-up records. Kaplan–Meier analysis and Cox regression model were used to assess overall survival according to the presence or absence of MCP-1 and CCR2 expression in tumor cells. MCP-1 was detected in cancer cells of 107 NSCLC (79.9 %) and CCR2 was detected in cancer cells of 39 NSCLC (29.1 %). MCP-1 expression was correlated with sex, smoking habits, histology, and tumor size. Presence of MCP-1 in tumor cells was associated with better overall survival (P = 0.018). By multivariate analysis, MCP-1 expression in cancer cells showed an independent prognostic factor for overall survival (P = 0.002, hazard ratio [HR] = 0.256, 95 % confidence interval [CI] = 0.106–0.616). There was no significant relationship between CCR2 expression in tumor cells and clinical and pathological characteristics. Also, no significant positive correlation between MCP-1 and CCR2 expression was revealed by Spearman correlation analysis. Our data indicate that MCP-1 is overexpressed in NSCLC cells. Its expression in cancer cells is associated with better survival in NSCLC patients.

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Abbreviations

NSCLC:

Non-small cell lung cancer

SCLC:

Small cell lung cancer

MCP-1:

Monocyte chemoattractant protein-1

CCR2:

CC chemokine receptor 2

TAM:

Tumor-associated macrophages

UICC:

International Union Against Cancer

AJCC:

American Joint Committee on Cancer

CCL2:

CC ligand 2

MMP-9:

Matrix metalloprotease-9

CTL:

Cytotoxic T cells

IFN:

Interferon

TNF:

Tumor necrosis factor

IL-1:

Interleukin 1

IL-2:

Interleukin 2

SNP:

Single-nucleotide polymorphism

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Correspondence to Hui-li Zhu.

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Zhang, Xw., Qin, X., Qin, C.Y. et al. Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance. Cancer Immunol Immunother 62, 563–570 (2013). https://doi.org/10.1007/s00262-012-1361-y

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  • DOI: https://doi.org/10.1007/s00262-012-1361-y

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