Skip to main content
Log in

Suggested pathway to assess radiation safety of 18F-labeled PET tracers for first-in-human studies

  • Letter to the Editor
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Zanotti-Fregonara P, Innis RB. Suggested pathway to assess radiation safety of (11)C-labeled PET tracers for first-in-human studies. Eur J Nucl Med Mol Imaging. 2012;39:544–7.

    Article  PubMed  Google Scholar 

  2. van der Aart J, Hallett WA, Rabiner EA, Passchier J, Comley RA. Radiation dose estimates for carbon-11-labelled PET tracers. Nucl Med Biol. 2012;39:305–14.

    Article  PubMed  Google Scholar 

  3. Sakata M, Oda K, Toyohara J, Ishii K, Nariai T, Ishiwata K. Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies. Ann Nucl Med. 2013;27:285–96.

    Article  PubMed  CAS  Google Scholar 

  4. Obrzut SL, Koren AO, Mandelkern MA, Brody AL, Hoh CK, London ED. Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies. Nucl Med Biol. 2005;32:869–74.

    Article  PubMed  CAS  Google Scholar 

  5. Bottlaender M, Valette H, Roumenov D, Dolle F, Coulon C, Ottaviani M, et al. Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers. J Nucl Med. 2003;44:596–601.

    PubMed  CAS  Google Scholar 

  6. Kimes AS, Horti AG, London ED, Chefer SI, Contoreggi C, Ernst M, et al. 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. FASEB J. 2003;17:1331–3.

    PubMed  CAS  Google Scholar 

  7. Adler L, Wolodzko J, Stabin M, McNelis T, Gammage L, Joshi A. Radiation dosimetry of F18-AV-45 measured by PET/CT in humans. J Nucl Med. 2008;49 Suppl 1:283.

    Google Scholar 

  8. Lin KJ, Hsu WC, Hsiao IT, Wey SP, Jin LW, Skovronsky D, et al. Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent – a pilot study. Nucl Med Biol. 2010;37:497–508.

    Article  PubMed  CAS  Google Scholar 

  9. Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med. 2010;51:913–20.

    Article  PubMed  CAS  Google Scholar 

  10. Giussani A, Janzen T, Uusijarvi-Lizana H, Tavola F, Zankl M, Sydoff M, et al. A compartmental model for biokinetics and dosimetry of 18F-choline in prostate cancer patients. J Nucl Med. 2012;53:985–93.

    Article  PubMed  CAS  Google Scholar 

  11. DeGrado TR, Reiman RE, Price DT, Wang S, Coleman RE. Pharmacokinetics and radiation dosimetry of 18F-fluorocholine. J Nucl Med. 2002;43:92–6.

    PubMed  CAS  Google Scholar 

  12. International Commission on Radiological Protection (ICRP). ICRP Publication 106: radiation dose to patients from radiopharmaceuticals—addendum 3 to ICRP publication 53. Ann ICRP. 2008;38 (1–2).

    Google Scholar 

  13. Deloar HM, Fujiwara T, Shidahara M, Nakamura T, Watabe H, Narita Y, et al. Estimation of absorbed dose for 2-[F-18]fluoro-2-deoxy-D-glucose using whole-body positron emission tomography and magnetic resonance imaging. Eur J Nucl Med. 1998;25:565–74.

    Article  PubMed  CAS  Google Scholar 

  14. International Commission on Radiological Protection (ICRP). ICRP Publication 62: radiological protection in biomedical research. Ann ICRP. 1992;22.

  15. Yaghoubi S, Barrio JR, Dahlbom M, Iyer M, Namavari M, Satyamurthy N, et al. Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med. 2001;42:1225–34.

    PubMed  CAS  Google Scholar 

  16. Tolvanen T, Lehtio K, Kulmala J, Oikonen V, Eskola O, Bergman J, et al. 18F-Fluoroerythronitroimidazole radiation dosimetry in cancer studies. J Nucl Med. 2002;43:1674–80.

    PubMed  CAS  Google Scholar 

  17. Doss M, Kolb HC, Zhang JJ, Belanger MJ, Stubbs JB, Stabin MG, et al. Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans. J Nucl Med. 2012;53:787–95.

    Article  PubMed  Google Scholar 

  18. Vesselle H, Grierson J, Peterson LM, Muzi M, Mankoff DA, Krohn KA. 18F-Fluorothymidine radiation dosimetry in human PET imaging studies. J Nucl Med. 2003;44:1482–8.

    PubMed  CAS  Google Scholar 

  19. Smolarz K, Krause BJ, Graner FP, Wagner FM, Hultsch C, Bacher-Stier C, et al. (S)-4-(3-18F-Fluoropropyl)-L-glutamic acid: an 18F-labeled tumor-specific probe for PET/CT imaging – dosimetry. J Nucl Med. 2013;54:861–6.

    Article  PubMed  CAS  Google Scholar 

  20. Beauregard JM, Croteau E, Ahmed N, van Lier JE, Benard F. Assessment of human biodistribution and dosimetry of 4-fluoro-11beta-methoxy-16alpha-18F-fluoroestradiol using serial whole-body PET/CT. J Nucl Med. 2009;50:100–7.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health (IRP-NIMH-NIH). Ioline Henter (NIMH) provided excellent editorial assistance.

Conflicts of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert B. Innis.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplemental Table 1

(DOCX 95 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zanotti-Fregonara, P., Lammertsma, A.A. & Innis, R.B. Suggested pathway to assess radiation safety of 18F-labeled PET tracers for first-in-human studies. Eur J Nucl Med Mol Imaging 40, 1781–1783 (2013). https://doi.org/10.1007/s00259-013-2512-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-013-2512-x

Keywords

Navigation