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A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer’s disease

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Abstract

Functional imaging methods such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) allow in vivo assessment of cerebral metabolism at rest and cerebral responses to cognitive stimuli. Activation studies with different cognitive tasks have deepened the understanding of underlying pathology leading to Alzheimer disease (AD) and how the brain reacts to and potentially compensates the imposed damage inflicted by this disease. The aim of this manuscript study was to summarize current findings of activation studies in healthy people at risk for AD, in people with mild cognitive impairment (MCI) as a possible progenitor of AD and finally in patients with manifest AD, adding recent results about impaired deactivation abilities and default mode function in AD. A new comprehensive model will be introduced integrating these heterogeneous findings and explaining their impact on cognitive performance.

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Author notes

  1. Marc Wermke

    Present address: Nuklearmedizinische Klinik u. Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, München, Germany

Authors and Affiliations

  1. Department of Nuclear Medicine, Technische Universität, München, 81675, Munich, Germany

    Marc Wermke & Alexander Drzezga

  2. Department of Psychiatry and Psychotherapy, Technische Universität, München, 81675, Munich, Germany

    Christian Sorg

  3. Departments of Neuroradiology and Neurology, Technische Universität, München, 81675, Munich, Germany

    Afra M. Wohlschläger

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  1. Marc Wermke
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  2. Christian Sorg
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  3. Afra M. Wohlschläger
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  4. Alexander Drzezga
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Correspondence to Marc Wermke.

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Wermke, M., Sorg, C., Wohlschläger, A.M. et al. A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer’s disease. Eur J Nucl Med Mol Imaging 35 (Suppl 1), 12–24 (2008). https://doi.org/10.1007/s00259-007-0698-5

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  • DOI: https://doi.org/10.1007/s00259-007-0698-5

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