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Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Previous cerebral blood flow and glucose metabolism studies suggest that the basal ganglia or thalamus is involved in the pathogenesis of paroxysmal kinesigenic choreoathetosis (PKC). However, the underlying cerebral abnormalities in idiopathic PKC have not been elucidated. To localise cerebral perfusion abnormalities in PKC, we performed interictal brain perfusion 99mTc-ethylcysteinate dimer (ECD) single-photon emission computed tomography (SPECT) in PKC patients and in normal controls.

Methods

Sixteen patients with idiopathic PKC and 18 age- and sex-matched normal controls were included. The patients were de novo diagnosed as having PKC, or had not taken medication for at least 3 months; none of them had structural abnormalities on MRI. Patients had a history of PKC attacks of a duration not exceeding 5 min and starting either on one side or on both sides of the body. These attacks were always induced by a sudden initiation of voluntary movement. PKC attacks were recorded in a hospital after being induced by neurology staff in 13 of the 16 patients. Interictal brain perfusion 99mTc-ECD SPECT was performed in all 16 patients and 18 normal controls. Differences between the cerebral perfusion in the PKC group and the normal control group were tested by statistical parametric mapping. Student’s t test was used for inter-group comparisons.

Results

Compared with normal controls, patients with idiopathic PKC showed interictal hypoperfusion in the posterior regions of the bilateral caudate nuclei (false discovery rate-corrected P<0.001 with a small volume correction).

Conclusion

This study showed that cerebral perfusion abnormality of bilateral caudate nuclei is present in idiopathic PKC.

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Acknowledgements

This work was supported by a grant (No. HMP-03-PJ1-PG3-21300-0033) of the Good Health R&D Project, Ministry of Health & Welfare, Republic of Korea.

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Authors and Affiliations

  1. Department of Neurology, Samsung Medical Center & Center for Clinical Medicine, SBRI, Sungkyunkwan University School of Medicine, Seoul, Korea

    Eun Yeon Joo, Seung Bong Hong, Woo Suk Tae, Jee Hyun Kim, Sun Jung Han & Dae Won Seo

  2. Department of Nuclear Medicine, Samsung Medical Center & Center for Clinical Medicine, SBRI, Sungkyunkwan University School of Medicine, Seoul, Korea

    Kyung-Han Lee & Byung Tae Kim

  3. Department of Computer Science and Engineering, Ewha Women’s University, Seoul, Korea

    Myoung-Hee Kim

  4. APCTP/NCSL, Department of Physics, POSTECH, Pohang, Korea

    Seunghwan Kim

  5. College of Pharmacy, Catholic University of Daegue, Gyongbook, Korea

    Mann Hyung Lee

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  1. Eun Yeon Joo
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Correspondence to Seung Bong Hong.

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Joo, E.Y., Hong, S.B., Tae, W.S. et al. Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis. Eur J Nucl Med Mol Imaging 32, 1205–1209 (2005). https://doi.org/10.1007/s00259-005-1814-z

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  • DOI: https://doi.org/10.1007/s00259-005-1814-z

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