Skip to main content
Log in

Biodistribution and radiation dosimetry of [123I]ADAM in healthy human subjects: preliminary results

  • Short Communication
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract.

[123I]ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM)] has recently been shown to be a very promising imaging ligand for the detection of serotonin transporters (SERT) in human brain, because of its high specificity for SERT. [123I]ADAM has previously been used only for animal studies. In this work, we investigated the radiation dosimetry and biodistribution of [123I]ADAM based on whole-body scans in healthy human volunteers. Following the administration of 196±20 MBq (range 157–220 MBq) [123I]ADAM, serial whole-body images were performed up to 24 h. Estimates of radiation absorbed dose were calculated using the MIRDOSE 3.0 program with a dynamic bladder model. Twelve source organs were considered in estimating absorbed radiation doses for organs of the body. The highest absorbed organ doses were found to the lower large intestine wall (8.3·10–2 mGy/MBq), kidneys (5.2·10–2 mGy/MBq), urinary bladder wall (4.9·10–2 mGy/MBq) and thyroid (4.3·10–2 mGy/MBq). The effective dose was estimated to be 2.2·10–2 mSv/MBq. The results suggest that [123I]ADAM is of potential value as a tracer for single-photon emission tomography imaging of serotonin receptors in humans, with acceptable dosimetry and high brain uptake.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Author information

Authors and Affiliations

Authors

Additional information

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kauppinen, T.A., Bergström, K.A., Heikman, P. et al. Biodistribution and radiation dosimetry of [123I]ADAM in healthy human subjects: preliminary results. Eur J Nucl Med 30, 132–136 (2003). https://doi.org/10.1007/s00259-002-1027-7

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-002-1027-7

Navigation