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Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing β-human chorionic gonadotropin

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Abstract

Giant cell tumor of bone is a benign, locally aggressive neoplasm that is composed of sheets of neoplastic mononuclear cells interspersed amongst non-neoplastic, uniformly distributed, osteoclast-like giant cells. They represent approximately 4–5 % of primary bone tumors. Rarely, bone tumors have been noted to produce human chorionic gonadotropin, a finding most often reported in osteosarcoma. We present the case of a young woman who presented with a low-level human chorionic gonadotropin level which, after resection of her recurrent giant cell tumor of bone with secondary aneurysmal bone cyst-like change, became undetectable in her blood. Furthermore, cells within the aneurysmal bone cyst component were immunohistochemically positive for β-human chorionic gonadotropin. This is the first report of such a finding in the literature.

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References

  1. Athanasou NA, Bansal M, Forsyth R, Reid RP, Sapi S. Giant cell tumor of bone. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO Classification of Tumors of Soft Tissue and Bone. Lyon: IARC Press; 2013. p. 321–4.

    Google Scholar 

  2. Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21:1283–309.

    Article  CAS  PubMed  Google Scholar 

  3. Kalra JK, Mir R, Kahn LB, Wessley Z, Shah AB. Osteogenic sarcoma producing human chorionic gonadotrophin: case report with immunohistochemical studies. Cancer. 1984;53:2125–8.

    Article  CAS  PubMed  Google Scholar 

  4. Tuy BE, Obafemi AA, Beebe KS, Patterson FR. Elevated serum beta human chorionic gonadotropin in a woman with osteosarcoma. Clin Orthop Relat Res. 2008;466:997–1001.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Ordonez NG, Ayala AG, Raymond AK, Plager C, Benjamin RS, Samaan NA. Ectopic production of the beta-subunit of human chorionic gonadotropin in osteosarcoma. Arch Pathol Lab Med. 1989;113:416–9.

    CAS  PubMed  Google Scholar 

  6. Boss DS, Glen H, Beijnen JH, et al. Serum β-hCG and CA-125 as tumor markers in a patient with osteosarcoma: case report. Tumori. 2011;97:109–14.

    CAS  PubMed  Google Scholar 

  7. Munshi HG, Merajver SD, Valdez R, Baker LH, Cooney KA. Metastatic dedifferentiated chordoma with elevated β-hCG. Am J Clin Oncol. 2002;25:274–6.

    Article  PubMed  Google Scholar 

  8. Mack GR, Robey DB, Kurman RJ. Chondrosarcoma secreting chorionic gonadotropin: report of a case. J Bone Joint Surg Am. 1977;59:1107–11.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Rutgers, the State University of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA

    Valerie A. Fitzhugh & Gordana Katava

  2. Department of Radiology, Rutgers, the State University of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA

    Cornelia Wenokor

  3. Department of Obstetrics, Gynecology, and Women’s Health, Rutgers, the State University of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA

    Natalie Roche

  4. Department of Orthopaedics, Rutgers, the State University of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA

    Kathleen S. Beebe

Authors
  1. Valerie A. Fitzhugh
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  2. Gordana Katava
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  3. Cornelia Wenokor
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  4. Natalie Roche
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  5. Kathleen S. Beebe
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Correspondence to Valerie A. Fitzhugh.

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Fitzhugh, V.A., Katava, G., Wenokor, C. et al. Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing β-human chorionic gonadotropin. Skeletal Radiol 43, 831–834 (2014). https://doi.org/10.1007/s00256-013-1785-2

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  • DOI: https://doi.org/10.1007/s00256-013-1785-2

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