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Multimodality treatment of a multifocal osteoblastoma-like tumor of the lower extremity

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Abstract

Osteoblastoma-like tumor is a rare condition with limited information on its orthopedic management in the current medical literature. The tumor histologically resembles an osteoblastoma, although the radiographic features are similar to those observed in primary vascular lesions. The treatment in the previously reported cases involved aggressive procedures including amputation, en bloc resection, and chemotherapy because of the uncertainty regarding the biological behavior of the tumor. We present a case of this entity that was successfully treated by a combination therapy including intralesional curettage with adjuvant cryotherapy, in situ and intravenous administration of bisphosphonates and radioablation.

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Acknowledgements

The authors would like to acknowledge Dr. Peter G. Bullough for providing the use of some of the material related to the case, Dr. Michael Kyriakos for detailed critical reading and valuable suggestions for the manuscript submission, Dr. Philip Rusli for expert technical assistance, and Mrs. Irina Shuleshko for histology preparations.

Funding

Cohn Foundation.

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery and Rehabilitation Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, 30, Brooklyn, NY, 11203, USA

    Jeffrey E. Mait

  2. Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    Giorgio Perino & Stephen Doty

  3. Department of Orthopaedic Surgery, Siriraj Hospital, Mahaidol University, 2 Prannok Road Siriraj, Angkokonoie, Bangkok, 10700, Thailand

    Aasis Unnanuntana

  4. Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    Tai-Li Chang & Joseph M. Lane

  5. Department of Radiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    Robert Schneider

Authors
  1. Jeffrey E. Mait
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  2. Giorgio Perino
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  3. Aasis Unnanuntana
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  4. Tai-Li Chang
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  5. Stephen Doty
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  6. Robert Schneider
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  7. Joseph M. Lane
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Corresponding authors

Correspondence to Jeffrey E. Mait or Giorgio Perino.

Appendix 1: Source and dilution of the antibodies used in this study

Appendix 1: Source and dilution of the antibodies used in this study

Antibody

Dilution

Catalogue number

Source

BMP-7

1:200

MAB3541

R&D Systems

Cathepsin K

1:500

MAB3324

Chemicon/Millipore

PCNA

1:100

Sc-56

Santa Cruz Biotechnology

Pro-collagen I

250ng/slide

SP1.D8

Developmental Studies Hybridoma Bank, University of Iowa

VEGF

1:100

Ab44724

Abcam

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Mait, J.E., Perino, G., Unnanuntana, A. et al. Multimodality treatment of a multifocal osteoblastoma-like tumor of the lower extremity. Skeletal Radiol 41, 1153–1161 (2012). https://doi.org/10.1007/s00256-011-1345-6

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  • DOI: https://doi.org/10.1007/s00256-011-1345-6

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