Skip to main content

Advertisement

SpringerLink
Log in

First report of a solid variant of aneurysmal bone cyst in the os sacrum

  • Case Report
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

We report on a 19-year-old woman with a rapidly growing, solid variant of aneurysmal bone cyst (solid ABC) in the right part of the lateral mass of the sacrum. On admission, the magnetic resonance imaging (MRI) scan disclosed an inhomogeneous low intensity mass right of the centre of the os sacrum with a diameter of 38 × 64 mm and a height of 56 mm on T1 and T2 weighted images. The mass showed homogenous high signal intensity on Gd-enhanced images. Computed tomography demonstrated an expansile osteolytic lesion and 99mTc-methylene diphosphonate bone scintigraphy revealed uniform accumulation in the lesion. The histological evaluation showed a proliferation of fibroblasts, histiocytes, chronic inflammatory cells and numerous multinucleated giant cells. Nevertheless, the cells were devoid of nuclear atypia. A cystic component was not observed. In spite of thorough curettage, the patient suffered from recurrence and severe neurological deficits. A review of the literature revealed no previous cases of solid ABC in the sacrum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Althof PA, Ohmori K, Zhou M, et al. Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization. Mod Pathol. 2004;17:518–25.

    Article  CAS  Google Scholar 

  2. Baruffi MR, Neto JB, Barbieri CH, Casartelli C. Aneurysmal bone cyst with chromosomal changes involving 7q and 16p. Cancer Genet Cytogenet. 2001;129:177–80.

    Article  CAS  Google Scholar 

  3. Leithner A, Bodo K, Scheipl S, Radl R, Kastner N, Windhager R. Two cases of calcaneal osteosarcomas presenting as aneurysmal bone cysts. Foot Ankle Int. 2004;25:815–8.

    Article  Google Scholar 

  4. Oliveira AM, Chou MM, Perez-Atayde AR, Rosenberg AE. Aneurysmal bone cyst: a neoplasm driven by upregulation of the USP6 oncogene. J Clin Oncol. 2006;24:e1.

    Article  Google Scholar 

  5. Wyatt-Ashmead J, Bao L, Eilert RE, Gibbs P, Glancy G, McGavran L. Primary aneurysmal bone cysts: 16q22 and/or 17p13 chromosome abnormalities. Pediatr Dev Pathol. 2001;4:418–9.

    Article  CAS  Google Scholar 

  6. Perrotti V, Rubini C, Fioroni M, Piattelli A. Solid aneurysmal bone cyst of the mandible. Int J Pediatr Otorhinolaryngol. 2004;68:1339–44.

    Article  Google Scholar 

  7. Schulte M, Sarkar MR, Von Baer A, Schultheiss M, Suger G, Hartwig E. Therapy of aneurysmal bone cyst. Unfallchirurg. 2000;103:115–21.

    Article  CAS  Google Scholar 

  8. Wang XL, Gielen JL, Salgado R, Delrue F, De Schepper AM. Soft tissue aneurysmal bone cyst. Skeletal Radiol. 2004;33:477–80.

    Article  CAS  Google Scholar 

  9. Kiattavorncharoen S, Joos U, Brinkschmidt C, Werkmeister R. Aneurysmal bone cyst of the mandible: a case report. Int J Oral Maxillofac Surg. 2003;32:419–22.

    Article  CAS  Google Scholar 

  10. Suzuki M, Satoh T, Nishida J, et al. Solid variant of aneurysmal bone cyst of the cervical spine. Spine. 2004;29:E376–E381.

    Article  Google Scholar 

  11. Sanerkin NG, Mott MG, Roylance J. An unusual intraosseous lesion with fibroblastic, osteoclastic, osteoblastic, aneurysmal and fibromyxoid elements: "solid" variant of aneurysmal bone cyst. Cancer. 1983;51:2278–86.

    Article  CAS  Google Scholar 

  12. HL JAFFE. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6:159–75.

    Article  Google Scholar 

  13. Oda Y, Tsuneyoshi M, Shinohara N. "Solid" variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones: a study of its morphologic spectrum and distinction from allied giant cell lesions. Cancer. 1992;70:2642–9.

    Article  CAS  Google Scholar 

  14. Ilaslan H, Sundaram M, Unni KK. Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. Am J Roentgenol. 2003;180:1681–7.

    Article  Google Scholar 

  15. Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21:1283–309.

    Article  CAS  Google Scholar 

  16. Laforga JB, Jover A, Martinez P. Soft-tissue osteosarcoma with prominent aneurysmatic bone cyst-like features: a case report. Diagn Cytopathol. 2001;24:209–14.

    Article  CAS  Google Scholar 

  17. Yamamoto T, Marui T, Akisue T, Mizuno K. Solid aneurysmal bone cyst in the humerus. Skeletal Radiol. 2000;29:470–3.

    Article  CAS  Google Scholar 

  18. Yamamoto T, Nagira K, Akisue T, et al. Fine-needle aspiration biopsy of solid aneurysmal bone cyst in the humerus. Diagn Cytopathol. 2003;28:159–62.

    Article  Google Scholar 

  19. Johnsson A, Collin A, Rydholm A, Domanski HA, Mertens F, Mandahl N. Unstable translocation (8;22) in a case of giant cell reparative granuloma. Cancer Genet Cytogenet. 2007;177:59–63.

    Article  CAS  Google Scholar 

  20. Gleason BC, Kleinman PK, Debelenko LV, Rahbar R, Gebhardt MC, Perez-Atayde AR. Novel karyotypes in giant cell-rich lesions of bone. Am J Surg Pathol. 2007;31:926–32.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Traumatology, Klinikum rechts der Isar, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany

    Helen Vester

  2. Department of Orthopedics, Klinikum Großhadern, Ludwigs-Maximilians-University Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Bernd Wegener, Volkmar Jansson & Hans Roland Dürr

  3. Institute of Pathology, Klinikum Großhadern, Ludwigs-Maximilians-University Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Christoph Weiler

  4. Department of Radiology, Klinikum Großhadern, Ludwigs-Maximilians-University Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Andrea Baur-Melnyk

Authors
  1. Helen Vester
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernd Wegener
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christoph Weiler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrea Baur-Melnyk
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Volkmar Jansson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hans Roland Dürr
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Helen Vester.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vester, H., Wegener, B., Weiler, C. et al. First report of a solid variant of aneurysmal bone cyst in the os sacrum. Skeletal Radiol 39, 73–77 (2010). https://doi.org/10.1007/s00256-009-0751-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-009-0751-5

Keywords

Search

Navigation