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Multifocal osseous involvement as the sole manifestation of Rosai-Dorfman disease

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Abstract

Rosai-Dorfman disease may involve extranodal sites exclusively. Osseous involvement as the sole manifestation of disease is uncommon. The present report describes a 60-year-old woman presenting with lytic lesions in the lower end of femur and mid-fibula on one side and unaccompanied by disease elsewhere.

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References

  1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 1969; 87:63–70.

    PubMed  Google Scholar 

  2. Lewin JR, Das SK, Blumenthal BI, D’Cruz C, Patel RB, Howell GE. Osseous pseudotumor, the sole manifestation of sinus histiocytosis with massive lymphadenopathy. Am J Clin Pathol 1985; 184:547–550.

    Google Scholar 

  3. Hamels J, Fiasse L, Thiery J. Atypical lymphohistiocytic tumor (osseous variant of Rosai-Dorfman disease). Virchows Arch [Pathol Anat] 1985; 408:183–189.

    Google Scholar 

  4. Nawroz IM, Wilson-Storey D. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Histopathology 1989; 14:91–99.

    PubMed  Google Scholar 

  5. Allegranza A, Barbareschi M, Solero CL, Fornari M, Lasio G. Primary lymphohistiocytic tumor of bone: a primary localisation of Rosai-Dorfman disease. Histopathology 1991;18:79–80.

    PubMed  Google Scholar 

  6. Shemen L, D’Anton M, Klijian A, Toth I, Galantich P. Rosai-Dorfman disease involving premaxilla. Ann Otol Rhinol Laryngol 1991; 100:845–851.

    PubMed  Google Scholar 

  7. Rasool MN, Ramdial PK. Osseous localization of Rosai-Dorfman disease. J Hand Surg 1996; 21:349–350.

    Google Scholar 

  8. Patterson FR, Rooney MT, Vermont AI, Hitchison RE. Sclerotic lesion of tibia without involvement of lymph nodes: report of an unusual case of Rosai-Dorfman disease. J Bone Joint Surg Am 1997; 79:911–916.

    PubMed  Google Scholar 

  9. Pavlovskia AL, Solov’ev IUN. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): bone manifestations. Arch Pathol 1997; 59:62–66.

    Google Scholar 

  10. Grote HJ, Moesenthin M, Foss HD, Kelow J, Roessner A. Osseous manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): a case report and review of literature. Gen Diagn Pathol 1998; 143:341–345.

    PubMed  Google Scholar 

  11. Park YK, Kim YW, Choi WS, Lim YJ. Sinus histiocytosis with massive lymphadenopathy: multiple skull involvements. J Korean Med Sci 1998; 13: 423–427.

    PubMed  Google Scholar 

  12. George J, Stacy G, Peabody T, Montag A. Rosai-Dorfman disease manifesting as a solitary lesion of the radius in a 41-year-old woman. Skeletal Radiol 2003; 32:236–239.

    PubMed  Google Scholar 

  13. Goel MM, Agarwal PK, Agarwal S. Primary Rosai-Dorfman disease of bone without lymphadenopathy diagnosed by fine needle aspiration cytology: A case report. Acta Cytol 2003; 47:1119–1122.

    PubMed  Google Scholar 

  14. Loh SY, Tan KB, Wong YS, Lee YS. Rosai-Dorfman disease of triquetrum without lymphadenopathy: a case report. J Bone Joint Surg Am 2004; 86:595–598.

    PubMed  Google Scholar 

  15. Abdelwahab IF, Klein MJ, Springfield DS, Hermann G. A solitary lesion of talus with sclerotic and lytic changes: Rosai-Dorfman disease of 25-years duration. Skeletal Radiol 2004; 34:230–233.

    Article  Google Scholar 

  16. Mota Gamboa JD, Caleiras E, Rosas-Uribe A. Extranodal Rosai-Dorfman disease. Clinical and pathological characteristics in patient with a pseudotumor of bone. Pathol Res Pract 2004; 200:423–426.

    Article  PubMed  Google Scholar 

  17. Foucar E, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990; 7:19–73.

    PubMed  Google Scholar 

  18. Walker PD, Rosai J, Dorfman RF. The osseous manifestations of sinus histiocytosis with massive lymphadenopathy. Am J Clin Pathol 1981; 75:137–139.

    Google Scholar 

  19. Sartoris DJ, Resnick D. Osseous involvement in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) (letter). Eur J Pediatr 1986; 145:238–240.

    Article  PubMed  Google Scholar 

  20. Pulsoni A, Anghel G, Falcucci P, Matera R, Pescarmona E, Ribersani M, Villiva N, Mandelli F. Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol 2002; 69:67–71.

    Article  PubMed  Google Scholar 

  21. Paulli M, Bergamaschi G, Tonon L et al. Evidence of polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy ( Rosai-Dorfman disease). Br J Haematol 1995; 91:415–418.

    PubMed  Google Scholar 

  22. Rosai J. Lymph nodes. In: Rosai J, ed. Rosai and Ackerman’s surgical pathology, 9th edn. St Louis: Mosby Elsevier 2004

  23. Tsang WYW, Yip TTC, Chan JKC. Rosai-Dorfman histiocytes are not infected by Epstein-Barr virus. Histopathology 1994; 25:88–90.

    PubMed  Google Scholar 

  24. Middel P, Hemmerlein B, Fayyazi A, Kabotti U, Radzun HJ. Sinus histiocytosis with massive lymphadenopathy. Evidence for its relationship to macrophages and for a cytokine-related disorder. Histopathology 1999; 35:525―533

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors gratefully acknowledge Dr. Juan Rosai for reviewing the histology slides and confirming the diagnosis.

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Correspondence to C. Sundaram.

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Sundaram, C., Shantveer G, U., Chandrashekar, P. et al. Multifocal osseous involvement as the sole manifestation of Rosai-Dorfman disease. Skeletal Radiol 34, 658–664 (2005). https://doi.org/10.1007/s00256-005-0951-6

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  • DOI: https://doi.org/10.1007/s00256-005-0951-6

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