Abstract
Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic, myotoxic, and many different enzymatic activities. Snake envenomation is a significant health issue as millions of snakebites are reported annually. A large number of people are injured and die due to snake venom poisoning. However, several fatal snake venom toxins have found potential uses as diagnostic tools, therapeutic agent, or drug leads. In this review, different non-enzymatically active snake venom toxins which have potential therapeutic properties such as antitumor, antimicrobial, anticoagulating, and analgesic activities will be discussed.
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Acknowledgments
We gratefully acknowledge the award of a Health and Medical Research Fund research grant (no. 12131221) from the Food and Health Bureau; Hong Kong Special Administration Region Government research grants (no. 81201270 and 81471927) from the National Natural Science Foundation of China, People’s Republic of China; and direct grants (no. 4054049 and 4054135) from the Medicine Panel, Research Committee, The Chinese University of Hong Kong and research grant (no. JCYJ20150525092941055) from the Science and Technology Innovation Commission of Shenzhen.
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YSC and RCFC were responsible for writing the review. TBN assisted in providing references for the manuscript. TBN, WYC, JHW, and LX did the final editing and proofreading of the manuscript. All authors reviewed the manuscript.
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Yau Sang Chan and Randy Chi Fai Cheung contributed equally to this work.
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Chan, Y.S., Cheung, R.C.F., Xia, L. et al. Snake venom toxins: toxicity and medicinal applications. Appl Microbiol Biotechnol 100, 6165–6181 (2016). https://doi.org/10.1007/s00253-016-7610-9
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DOI: https://doi.org/10.1007/s00253-016-7610-9