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Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17

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Abstract

Canine atopic dermatitis (AD) is an allergic inflammatory skin disease that shares similarities with AD in humans. Canine AD is likely to be an inherited disease in dogs and is common in West Highland white terriers (WHWTs). We performed a genome-wide association study using the Affymetrix Canine SNP V2 array consisting of over 42,800 single nucleotide polymorphisms, on 35 atopic and 25 non-atopic WHWTs. A gene-dropping simulation method, using SIB-PAIR, identified a projected 1.3 Mb area of association (genome-wide P = 6 × 10−5 to P = 7 × 10−4) on CFA 17. Nineteen genes on CFA 17, including 1 potential candidate gene (PTPN22), were located less than 0.5 Mb from the interval of association identified on the genome-wide association analysis. Four haplotypes within this locus were differently distributed between cases and controls in this population of dogs. These findings suggest that a major locus for canine AD in WHWTs may be located on, or in close proximity to an area on CFA 17.

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Acknowledgments

This work was supported by the Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland; the Australian Companion Animal Health Foundation; and the John and Mary Kibble Trust. The authors also thank the owners of the WHWTs involved in this study, especially Lyndell Sequil Bristow.

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Authors and Affiliations

  1. School of Veterinary Science, The University of Queensland, 4343, Gatton, QLD, Australia

    Joana B. Roque, Myat Kyaw-Tanner, Puya Gharahkhani & Melanie Latter

  2. Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, 4069, St Lucia, QLD, Australia

    Caroline A. O’Leary

  3. Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, 4029, Herston, QLD, Australia

    David L. Duffy

  4. University Veterinary Teaching Hospital, The University of Sydney, 2570, Camden, NSW, Australia

    Linda Vogelnest

  5. Dermcare, 22 Aranda St, 4127, Springwood, QLD, Australia

    Kenneth Mason

  6. Dermatology for Animals, 263 Appleby Rd, 4053, Stafford Heights, QLD, Australia

    Michael Shipstone

Authors
  1. Joana B. Roque
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  2. Caroline A. O’Leary
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  3. David L. Duffy
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  7. Kenneth Mason
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  9. Melanie Latter
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Corresponding author

Correspondence to Caroline A. O’Leary.

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Supplementary Table 1

Table with conserved sequences in the 1.3-Mb region of CFA 17 with significant P values based on the Rank VISTA scores (Martin et al. 2004). (PDF 161 kb)

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Roque, J.B., O’Leary, C.A., Duffy, D.L. et al. Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17. Immunogenetics 64, 209–217 (2012). https://doi.org/10.1007/s00251-011-0577-x

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  • DOI: https://doi.org/10.1007/s00251-011-0577-x

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