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Human Intestinal Microbiota Gene Risk Factors for Antibiotic-Associated Diarrhea: Perspectives for Prevention

Risk Factors for Antibiotic-Associated Diarrhea

  • Genes and Genomes
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Abstract

Antibiotic-associated diarrhea (AAD) is associated with altered intestinal microflora and other symptoms that may lead to possibly death. In critically ill patients, diarrhea increases rates of morbimortality. Assessing diarrhea risks is thus important for clinicians. For this reason, we conducted a hypothesis-generating study focused on AAD to provide insight into methods of prevention. We evaluated the hypothesis of predisposing factors within the resident intestinal microbiota in a cohort of outpatients receiving antibiotherapy. Among the pool of tested variables, only those related to bacterial 16S rRNA genes were found to be relevant. Complex statistical analyses provided further information: amid the bacteria 16S rRNA genes, eight were determined to be essential for diarrhea predisposition and characterized from the most important to the least. Using these markers, AAD risk could be estimated with an error of 2%. This molecular analysis offers new perspectives for clinical applications at the level of prevention.

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Acknowledgments

We thank Dr. Bertrand D. from INRA, Unité de Sensometrie-Chimiometrie (Nantes, France) for his assistance in this investigation.

Financial support

Biocodex, Inc.

Potential conflicts of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, Université de Nantes – INSERM, UFR Médecine, 1 rue Gaston Veil, Nantes, 44000, France

    Marie-France de La Cochetière

  2. Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, Université de Nantes, UFR Médecine, 1 rue Gaston Veil, Nantes, 44000, France

    Emmanuel Montassier, Thomas Carton, Tony Durand & Gilles Potel

  3. Biostatistics Clinical Research and Subjective Measures in Health Sciences, EA4275, Université de Nantes, UFR Médecine et Pharmacie, 1 rue Gaston Veil, Nantes, 44000, France

    Jean-Benoit Hardouin

  4. Atlangene®-Silliker, Bio Ouest, Ile de Nantes, 21 rue La Noue Bras de Fer, Nantes, 44000, France

    Françoise Le Vacon

  5. Service de Gastro-entérologie et Nutrition, Hôpital Saint-Antoine, 184 rue du faubourg Saint-Antoine, Paris, Cedex 75012, France

    Valerie Lalande, Jean Claude Petit & Laurent Beaugerie

Authors
  1. Marie-France de La Cochetière
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  2. Emmanuel Montassier
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  3. Jean-Benoit Hardouin
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  4. Thomas Carton
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  5. Françoise Le Vacon
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  6. Tony Durand
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  7. Valerie Lalande
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  8. Jean Claude Petit
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  9. Gilles Potel
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  10. Laurent Beaugerie
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Corresponding author

Correspondence to Marie-France de La Cochetière.

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de La Cochetière, MF., Montassier, E., Hardouin, JB. et al. Human Intestinal Microbiota Gene Risk Factors for Antibiotic-Associated Diarrhea: Perspectives for Prevention. Microb Ecol 59, 830–837 (2010). https://doi.org/10.1007/s00248-010-9637-2

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  • DOI: https://doi.org/10.1007/s00248-010-9637-2

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