Skip to main content

Advertisement

SpringerLink
Log in

Pulmonary interstitial glycogenosis in the setting of lung growth abnormality: radiographic and pathologic correlation

  • Case Report
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Pulmonary interstitial glycogenosis (PIG) is a rare pediatric interstitial lung disease. We report a case of a term boy presenting with tachypnea at birth requiring supplemental oxygen. Chest radiographs followed by high-resolution CT (HRCT) demonstrated hyperinflation and diffuse interstitial markings interspersed with multiple cystic spaces. An open lung biopsy demonstrated a minor component of PIG superimposed upon poor alveolarization. PIG in the setting of lung growth abnormality might be more common than previously described. Additionally, radiographic findings associated with most pediatric interstitial lung diseases are nonspecific, and histopathologic correlation is essential for diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Fan LL, Langston C (2006) Interstitial lung disease. In: Kendig’s disorders of the respiratory tract in children, 7th edn, pp 666–675

  2. Canakis A-M, Cutz E, Manson D et al (2002) Pulmonary interstitial glycogenosis: a new variant of neonatal interstitial lung disease. Am J Respir Crit Care Med 165:1557–1565

    Article  PubMed  Google Scholar 

  3. Deutsch GH, Young LR, Fan LL et al (2007) Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med 176:1120–1128

    Article  PubMed  Google Scholar 

  4. Onland W, Molenaar JJ, Leguit RJ et al (2005) Pulmonary interstitial glycogenosis in identical twins. Pediatr Pulmonol 40:362–366

    Article  CAS  PubMed  Google Scholar 

  5. Schroeder SA, Shannon DC, Mark EJ (1992) Cellular interstitial pneumonitis in infants: a clinicopathologic study. Chest 101(4):1065–1069

    Article  CAS  PubMed  Google Scholar 

  6. Katzenstein AL, Gordon LP, Oliphant M et al (1995) Chronic pneumonitis of infancy. A unique form of interstitial lung disease occurring in early childhood. Am J Surg Pathol 19:439–447

    Article  CAS  PubMed  Google Scholar 

  7. Deterding RR, Pye C, Fan LL et al (2005) Persistent tachypnea of infancy is associated with neuroendocrine cell hyperplasia. Pediatr Pulmonol 40:157–165

    Article  PubMed  Google Scholar 

  8. Olsen ØE, Sebire NJ, Jaffe A et al (2004) Chronic pneumonitis of infancy: high-resolution CT findings. Pediatr Radiol 34:86–88

    Article  Google Scholar 

Download references

Author information

Author notes

  1. Emi Masuda

    Present address: Department of Radiology, Henry Ford Hospital, Detroit, MI, USA

Authors and Affiliations

  1. Department of Radiology, Loyola University Health System, 2160 S. First Ave., Maywood, IL, 60153, USA

    Monette Castillo, Aruna Vade & Jennifer Eden Lim-Dunham

  2. Department of Pathology, Loyola University Health System, Maywood, IL, USA

    Rasan Massarani-Wafai

Authors
  1. Monette Castillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aruna Vade
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jennifer Eden Lim-Dunham
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Emi Masuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rasan Massarani-Wafai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Monette Castillo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castillo, M., Vade, A., Lim-Dunham, J.E. et al. Pulmonary interstitial glycogenosis in the setting of lung growth abnormality: radiographic and pathologic correlation. Pediatr Radiol 40, 1562–1565 (2010). https://doi.org/10.1007/s00247-010-1670-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-010-1670-2

Keywords

Search

Navigation