Abstract
A 10-year-old boy with congenital immunodeficiency (X-linked agammaglobulinaemia) presented with loss of appetite and weight, right-sided abdominal pain, diarrhoea and low-grade fever. Radiological investigations with barium follow-through, CT, PET and octreotide scans revealed a primary caecal/ascending proximal colonic mass with liver and bony metastases. Urine screen for 5HIAA was positive. Percutaneous liver biopsy confirmed the diagnosis of neuroendocrine carcinoma. The radiological work-up and the usefulness of various imaging modalities in the diagnosis of this rare paediatric tumour are discussed. The PET scan demonstrated the primary tumour and the metastatic locations more vividly than the octreotide scan, which is currently considered to be the most specific imaging modality for neuroendocrine masses.
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Kanamalla US, Kesava PP, McGuff HS (2000) Imaging of nonlaryngeal neuroendocrine carcinoma. AJNR 21:775–778
Broaddus RR, Herzog CE, Hicks MJ (2003) Neuroendocrine tumours (carcinoid and neuroendocrine carcinoma) presenting at extra-appendiceal sites in childhood and adolescence. Arch Pathol Lab Med 127:1200–1203
Mitry E, Baudin E, Ducreux M, et al (1999) Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin. Br J Cancer 81:1351–1355
Spunt SL, Pratt CB, Rao BN (2000) Childhood carcinoid tumors: the St Jude Children’s Research Hospital experience. J Pediatr Surg 35:1282–1286
Belhocine T, Foidart J, Rigo P, et al (2002) Fluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67. Nucl Med Commun 23:727–734
Adams S, Baum R, Rink T, et al (1998) Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumours. Eur J Nucl Med 25:79–83
LeRest C, Bomanji JB, Costa DC, et al (2001) Functional imaging of malignant paragangliomas and carcinoid tumours. Eur J Nucl Med 28:478–482
Mueller BU, Pizzo PA (1995) Cancer in children with primary or secondary Immunodeficiencies. J Pediatr 126:1–10
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Sasi, O.A., Sathiapalan, R., Rifai, A. et al. Colonic neuroendocrine carcinoma in a child. Pediatr Radiol 35, 339–343 (2005). https://doi.org/10.1007/s00247-004-1319-0
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DOI: https://doi.org/10.1007/s00247-004-1319-0