Skip to main content
SpringerLink
Log in

Spinal MRI of vincristine neuropathy mimicking Guillain-Barré syndrome

  • Case Report
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

A 4.3-year-old girl with acute leukaemia, who was being treated with chemotherapy (including vincristine), developed paraplegia. Spinal MRI showed diffusely enhancing nerve roots on contrast-enhanced images. Spinal fluid analysis showed a normal protein level. Vincristine neuropathy mimicking Guillain-Barré syndrome is thought to be the cause of the MRI abnormalities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1a–d.

Similar content being viewed by others

References

  1. Wang MS, Wu Y, Culver DG, et al (2000) Pathogenesis of axonal degeneration: parallels between Wallerian degeneration and vincristine neuropathy. J Neuropathol Exp Neurol 59:599–606

    CAS  PubMed  Google Scholar 

  2. Baran GA, Sowell MK, Sharp GB, et al (1993) MR findings in a child with Guillain-Barré syndrome. AJR Am J Roentgenol 161:161–163

    CAS  Google Scholar 

  3. Norman M, Elinder G, Finkel Y (1987) Vincristine neuropathy and Guillain-Barré syndrome: a case with acute lymphatic leukemia and quadriparesis. Eur J Haematol 39:75–76

    CAS  PubMed  Google Scholar 

  4. Moudgil SS, Riggs JE (2000) Fulminant peripheral neuropathy with severe quadriparesis associated with vincristine therapy. Ann Pharmacother 34:1136–1138

    Article  CAS  PubMed  Google Scholar 

  5. Casey EB, Jellife AM, Le Quesen PM, et al (1973) Vincristine neuropathy. Clinical and electrophysiological observation. Brain 96:69–86

    CAS  PubMed  Google Scholar 

  6. Neumann Y, Toren A, Rechavi G, et al (1996) Vincristine treatment triggering the expression of asymptomatic Charcot-Marie-Tooth disease. Med Pediatr Oncol 26:280–283

    Article  CAS  PubMed  Google Scholar 

  7. Weiden PL, Wright SE (1972) Vincristine neurotoxicity. N Engl Med 286:1369–1370

    CAS  Google Scholar 

  8. Byun WM, Park WK, Park BH, et al (1998) Guillain-Barré syndrome: MR imaging findings of the spine in eight patients. Radiology 208:137–141

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-gu,, Seoul 135-710, Korea

    Yun Woo Chang, Hye-Kyung Yoon & Jae Min Cho

  2. Department of Paediatrics, Samsung Medical Centre, Seoul 135-710, Korea

    Ki Woong Sung

Authors
  1. Yun Woo Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hye-Kyung Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jae Min Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ki Woong Sung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hye-Kyung Yoon.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, Y.W., Yoon, HK., Cho, J.M. et al. Spinal MRI of vincristine neuropathy mimicking Guillain-Barré syndrome. Pediatr Radiol 33, 791–793 (2003). https://doi.org/10.1007/s00247-002-0849-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-002-0849-6

Keywords

Search

Navigation