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Coding Single-Nucleotide Polymorphisms of Interleukin-1 Gene Cluster Are Not Associated with Kawasaki Disease in the Korean Population

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Abstract

This study aimed to examine whether coding single-nucleotide polymorphisms (cSNPs) of the interleukin-1 gene cluster [interleukin-1-alpha (IL1α), IL1β, IL-1-receptor antagonist (IL1RN)] are genetic markers of susceptibility to Kawasaki disease (KD) in the Korean population. The study enrolled 109 KD patients and 287 healthy control subjects. Four cSNPs [rs17561 (Ala114Ser) of IL1α, rs1143634 (Phe105Phe) of IL1β, and rs419598 (Ala23Ala) and rs315952 (Ser96Ser) of IL1RN] were genotyped using the restriction fragment-length polymorphism (RFLP) and direct sequencing. The KD patients were divided into two groups according to the presence of coronary artery lesions (CALs). For genetic analysis, SNPStats, HapAnalyzer, Helixtree, and SNPAnalyzer were used. The allele and genotype frequencies of the IL1 gene cluster polymorphisms in the KD patients had a pattern similar to that in the control subjects. Furthermore, no association was observed between four cSNPs of the IL1 gene cluster and the development of CALs in KD. These results suggest that the IL1 gene cluster may not be associated with susceptibility to KD and the development of CALs in the Korean population.

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Acknowledgments

This study was supported by a grant from Kyung Hee University in 2004 (KHU 20040340).

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Authors and Affiliations

  1. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea

    Su Kang Kim, Sung Wook Kang, Joo-Ho Chung, Jong Seok Lee & Hyun Kyung Park

  2. Department of Pediatrics, East-West Neo Medical Center, Kyung Hee University, Sangil-dong, Gangdong-gu, Seoul, 134-890, Republic of Korea

    Kyung Lim Yoon

  3. Department of Thoracic and Cardiovascular Surgery, Kyung Hee University Medical Center, Kyung Hee University, Hoegi-dong, Dongdarmun-gu, Seoul, 130-702, Republic of Korea

    Soo Cheol Kim

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  1. Su Kang Kim
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  2. Sung Wook Kang
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  3. Joo-Ho Chung
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  4. Jong Seok Lee
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Correspondence to Soo Cheol Kim.

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Kim, S.K., Kang, S.W., Chung, JH. et al. Coding Single-Nucleotide Polymorphisms of Interleukin-1 Gene Cluster Are Not Associated with Kawasaki Disease in the Korean Population. Pediatr Cardiol 32, 381–385 (2011). https://doi.org/10.1007/s00246-010-9858-7

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  • DOI: https://doi.org/10.1007/s00246-010-9858-7

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