Skip to main content
SpringerLink
Log in

The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α-tocopherol in rat kidneys

  • ORIGINAL PAPER
  • Published:
Urological Research Aims and scope Submit manuscript

Abstract

Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over α-tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAPE at 10 μmol/kg or α-tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAPE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than α-tocopherol. CAPE may therefore offer a therapeutic advantage in acute injury settings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, İnonu University, Malatya, Turkey, , , , , , TR

    M. Kemal Irmak, Hüseyın Özyurt & Ömer Akyol

  2. Department of Pediatric Surgery, Faculty of Medicine, İnonu University, Malatya, Turkey e-mail: ukoltuksuz@inonu.edu.tr Tel.: +90-422-3113759; Fax: +90-422-3410728, , , , , , TR

    Uğur Koltuksuz & Abdurrahman Karaman

  3. Department of Pediatrics, Faculty of Medicine, İnonu University, Malatya, Turkey, , , , , , TR

    N. Onur Kutlu

  4. Department of Histology and Embryology, Faculty of Medicine, İnonu University, Malatya, Turkey, , , , , , TR

    Murat Yağmurca

Authors
  1. M. Kemal Irmak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Uğur Koltuksuz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Onur Kutlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Murat Yağmurca
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hüseyın Özyurt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Abdurrahman Karaman
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ömer Akyol
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 9 October 2000 / Accepted: 23 February 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Irmak, M., Koltuksuz, U., Kutlu, N. et al. The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α-tocopherol in rat kidneys. Urological Research 29, 190–193 (2001). https://doi.org/10.1007/s002400100185

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002400100185

Search

Navigation