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Prostate lymphoscintigraphy for sentinel lymph node identification in canines: reproducibility, uptake, and biokinetics depending on different injection strategies

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Abstract

At present there are neither clinical nor experimental data available on the influence of technical details on the quality and reproducibility of prostate lymphoscintigraphy. Six adult fox hounds received repeated transrectal ultrasound guided intraprostatic injections of a technetium 99m labeled nanocolloid to prove the influence of different techniques of injection (one central injection in both prostate lobes vs two peripheral injections in both lobes) on tracer accumulation in sentinel lymph nodes (SLN) and other organs. The reproducibility of the favored technique was examined and in a last step it was subject to scrutiny following a reduction of the injected volume to 1% of the prostate volume. The number of scintigraphically visualized SLN varied between four and seven. They were located in the region of the internal and external iliac vessels, presacrally, paravesically, and directly paraprostatically. In five of six cases, the localization was reproducible both with the central application of an identical volume as well as with the volume reduced central injection. Tracer accumulation of SLNs and other organs varied enormously. We expect that with the combination of both injection techniques, even with the reduced injection volume, an optimized prostate lymphoscintigraphy will be the outcome.

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Acknowledgments

The authors wish to thank Mr. Keil for his assistance in translation, Mrs. Grahneis and Mr. Finke for their assistance in prostate lymphoscintigraphy imaging, and Mr. Henning from the Institute of Medical Statistics, Technische Universität München, who designed the study. The study was supported by the Deutsche Forschungsgemeinschaft (DFG), Wa 1533/1-1, Bonn, Germany.

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Authors and Affiliations

  1. Department of Urology, Central Hospital Augsburg, Academic Hospital of the Ludwig Maximilians Universität München, Stenglinstrasse 2, 86156, Augsburg, Germany

    Friedhelm Wawroschek, Michael Hamm & Rolf Harzmann

  2. Department of Nuclear Medicine, Central Hospital Augsburg, Academic Hospital of the Ludwig Maximilians Universität München, Germany

    Hermann Wengenmair

  3. Department of Nuclear Medicine, Technische Universität München, Germany

    Reingard Senekowitsch-Schmidtke

  4. Institute for Experimental Oncology and Therapy Research, Technische Universität München, Germany

    Julia Henke, Tanja Schönberger, Andrea Hauser & Wolf Erhardt

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  1. Friedhelm Wawroschek
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  2. Hermann Wengenmair
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  3. Reingard Senekowitsch-Schmidtke
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  4. Michael Hamm
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  5. Julia Henke
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  6. Tanja Schönberger
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  7. Andrea Hauser
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  8. Wolf Erhardt
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  9. Rolf Harzmann
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Correspondence to Friedhelm Wawroschek.

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Wawroschek, F., Wengenmair, H., Senekowitsch-Schmidtke, R. et al. Prostate lymphoscintigraphy for sentinel lymph node identification in canines: reproducibility, uptake, and biokinetics depending on different injection strategies. Urol Res 31, 152–158 (2003). https://doi.org/10.1007/s00240-003-0307-4

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  • DOI: https://doi.org/10.1007/s00240-003-0307-4

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