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Application of diffusion-weighted imaging combined with apparent diffusion coefficient in differential diagnosis between central neurocytoma and ependymoma

  • Diagnostic Neuroradiology
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Abstract

Purpose

Differential diagnosis between central neurocytoma and ependymoma is very important for making preoperative scheme. We explored the application of diffusion-weighted imaging (DWI) combined with apparent diffusion coefficient (ADC) in differential diagnosis between both.

Methods

The data of preoperative MR plain and contrast-enhanced scan, DWI and ADC values of neoplastic solid parts from 18 cases with central neurocytoma and 19 cases with lateral ventricular ependymoma, were retrospectively analyzed. Mann-Whitney test was used for the comparison of ADC values between central neurocytoma and ependymoma. The application of ADC values in the differential diagnosis between central neurocytoma and ependymoma was evaluated by ROC curve.

Results

The lesions showed hyperintensity-dominant mixed signal intensity on DWI and mean ADC was (0.65 ± 0.13) × 10−3 mm2/s in the 18 cases with central neurocytoma. In the 19 cases with ependymoma, 13 had hyperintensity-dominant mixed signal intensity on DWI and 6 had hypointensity-dominant mixed signal intensity on DWI, and mean ADC was (1.20 ± 0.23) × 10−3 mm2/s. The mean ADC value was significantly higher in the 19 cases with ependymoma than in the 18 cases with central neurocytoma (P < 0.001). The ADC of 0.87 × 10−3 mm2/s might be used as a threshold for differential diagnosis between central neurocytoma and ependymoma with an area under ROC curve of 0.98 ± 0.02 and a 95% confidence interval of 0.95–1.00. Its sensitivity, specificity, and accuracy were 90%, 100%, and 90%, respectively.

Conclusion

There is a certain overlap in MRI imaging features between central neurocytoma and ependymoma. DWI combined with ADC value can improve peoperative diagnostic accuracy.

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  1. Department of Radiotherapy, Second Hospital Affiliated to Lanzhou University, No.82 Cuiyingmen, Chengguan District, Lanzhou, 730030, Gansu, China

    Peng-fei Sun, Li Ma, Bin-qiang Ye & Ya-ya Pei

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  1. Peng-fei Sun
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  2. Li Ma
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Correspondence to Peng-fei Sun.

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This study has been approved by the ethics committee of Second Hospital Affiliated to Lanzhou University.

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The patients reported in this study gave written informed consent to participate.

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Sun, Pf., Ma, L., Ye, Bq. et al. Application of diffusion-weighted imaging combined with apparent diffusion coefficient in differential diagnosis between central neurocytoma and ependymoma. Neuroradiology 62, 439–445 (2020). https://doi.org/10.1007/s00234-019-02342-6

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  • DOI: https://doi.org/10.1007/s00234-019-02342-6

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