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Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury

  • Functional Neuroradiology
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Abstract

Purpose

We utilized cerebral blood volume (CBV) magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate changes in cognitive networks in patients experiencing cognitive dysfunction following electrical injury.

Methods

Cognitive function was assessed across various domains, including attention, verbal memory, executive function, and language. Depressive symptoms were also evaluated. CBV maps and DTI measures were obtained from 24 patients (age, 41.8 ± 5.8 years; education, 13.3 ± 1.9 years) and 24 healthy controls (age, 42.3 ± 2.7 years; education, 14.3 ± 1.9 years). CBV maps and DTI measures were compared between patients and controls, and correlations between these measures and each cognitive assessment score were examined.

Results

Patients exhibited lower attention, verbal memory, and executive function scores than controls (all p < 0.01). Patients also exhibited higher depression scores than controls (p < 0.01), as well as a predominant increase in CBV in the cerebellar vermis relative to that of controls (height p < uncorrected 0.001, extent p < corrected 0.05). Correlation analyses revealed a strong association between executive function scores and CBV in the bilateral posterior cingulate cortex and left mammillary body in patients (height p < uncorrected 0.001, extent p < corrected 0.05). There were no significant differences in DTI measures between patients and controls.

Conclusion

The CBV maps showed hypermetabolism in the cerebello-limbic system; DTI did not find any microstructural changes. Our results suggest that patients experiencing cognitive dysfunction following electrical injury may possess a cognitive reserve that protects against deteriorating conditions such as dementia.

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Author information

Author notes

  1. C-hP and CHS contributed equally to this study and are joint first authors.

Authors and Affiliations

  1. Department of Psychiatry, College of Medicine, Catholic University of Korea, 222 Banpo-daero Seocho-gu, Seoul, 06591, Republic of Korea

    Chang-hyun Park

  2. Department of Physical Medicine and Rehabilitation, Hangang Sacred Heart Hospital, Hallym University College of Medicine, 12 Beodeunaru-ro 7 Gil Yeongdeungpo-gu, Seoul, 07247, Republic of Korea

    Cheong Hoon Seo & So Young Joo

  3. Department of Psychiatry, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170 Beon-gil, Dongan-gu Anyang, Gyeonggi-do, 14068, Republic of Korea

    Myung Hun Jung

  4. Department of Physical Medicine and Rehabilitation, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170 Beon-gil, Dongan-gu Anyang, Gyeonggi-do, 14068, Republic of Korea

    Soyeon Jang, Ho Young Lee & Suk Hoon Ohn

Authors
  1. Chang-hyun Park
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  2. Cheong Hoon Seo
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Corresponding author

Correspondence to Suk Hoon Ohn.

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Funding

This study was funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2014R1A1A1006893) and the Hallym University Research Fund 2014 (HURF-2014-06).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study involving human participants were approved by the institutional review board of Hallym University Sacred Heart Hospital (IRB No. 2014-I049) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Park, Ch., Seo, C.H., Jung, M.H. et al. Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury. Neuroradiology 59, 915–921 (2017). https://doi.org/10.1007/s00234-017-1876-1

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  • DOI: https://doi.org/10.1007/s00234-017-1876-1

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