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Predictive value of PWI for blood supply and T1-spin echo MRI for consistency of pituitary adenoma

  • Functional Neuroradiology
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Abstract

Introduction

It is a common view that consistency and blood supply of pituitary adenoma (PA) can influence the surgical effect. The aim of this study was to determine whether MRI signal intensity (SI) was correlated to the consistency or blood supply of pituitary macroadenoma.

Methods

Forty eight pituitary macroadenoma patients were underwent preoperative MRI, including precontrast and contrast-enhanced (CE) T1-spin echo (T1-SE) imaging, CE-sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) imaging, and perfusion-weighted imaging (PWI). The tumor consistency and blood supply were determined by neurosurgeons. The expression of collagen IV and MIB-1 was detected with immunohistology. The correlation of the relative SI (rSI) values (tumor to normal frontal white matter SI) and PWI data to the tumor consistency, blood supply, and the expression level of collagen IV and MIB-1 was statistically studied by Kruskal–Wallis rank test (K–W test).

Results

A significant correlation was observed between the tumor consistency and the rSI on precontrast T1-SE imaging (P = 0.004) but not on CE T1-SE and CE SPACE imaging. The expression of collagen IV was also significantly associated with rSI on T1-SE imaging (P = 0.010). The blood supply was correlated with the relative CBV (rCBV) (P = 0.030). In addition, the expression of MIB-1 was correlated with rSI of CE T1-SE imaging (P = 0.007).

Conclusion

Our results suggest that T1-SE imaging may be a simple and useful method for predicting consistency of PA. CBV value can provide helpful information for assessing the blood supply of pituitary macroadenoma.

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Acknowledgments

This research was supported by China Pituitary Adenoma Specialist Council (CPASC) and has received funding from the National Program for Support of Top-Notch Young Professionals, the National High Technology Research and Development Program of China (No.2014AA020611), the National Natural Science Foundation of China (No.81172391) and the Shanghai Rising-Star Tracking Program (12QH1400400) to YZ.

Ethical standards and patient consent

We declare that all human studies have been approved by the Ethics Committee at Huashan Hospital and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Author notes

    Authors and Affiliations

    1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China

      Zengyi Ma, Wenqiang He, Yao Zhao, Qilin Zhang, Shiqi Li & Yongfei Wang

    2. Shanghai Pituitary Tumor Center, Shanghai, China

      Zengyi Ma, Wenqiang He, Yao Zhao, Qilin Zhang, Shiqi Li & Yongfei Wang

    3. Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

      Jie Yuan, Yue Wu & Zhenwei Yao

    4. Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

      Hong Chen

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    1. Zengyi Ma
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    Correspondence to Yongfei Wang.

    Additional information

    ZM and WH contributed equally to this work.

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    Ma, Z., He, W., Zhao, Y. et al. Predictive value of PWI for blood supply and T1-spin echo MRI for consistency of pituitary adenoma. Neuroradiology 58, 51–57 (2016). https://doi.org/10.1007/s00234-015-1591-8

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    • DOI: https://doi.org/10.1007/s00234-015-1591-8

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