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Diagnosis of moyamoya disease using 3-T MRI and MRA: value of cisternal moyamoya vessels

  • Diagnostic Neuroradiology
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Abstract

Introduction

The purpose of this study was to propose new magnetic resonance (MR) criteria of diagnosing moyamoya disease (MMD) from cisternal moyamoya vessels (MMVs) on 3-T magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA) and compare the diagnostic accuracy of the existing MR criteria and the proposed MR criteria.

Methods

Participants comprised 20 consecutive patients with MMD (4 males, 16 females) diagnosed clinically using conventional angiography and 20 controls (13 male and 7 female arteriosclerosis patients). In these participants, 3-T MRI/MRA was evaluated by the existing MR criteria, which use MMVs in the basal ganglia, and the proposed MR criteria, which use cisternal MMVs, and then these two criteria were statistically compared by McNemar’s test.

Results

Diagnostic accuracy was 62.5% with the existing MR criteria and 97.5% with the proposed MR criteria. The proposed MR criteria was more sensitive (1.00) than the existing MR criteria (0.45), but less specific (0.95) than the existing MR criteria (1.00).

Conclusion

The proposed MR criteria using cisternal MMVs showed significantly higher diagnostic accuracy than the existing MR criteria. We believe that our proposed MR criteria will be beneficial for diagnosing MMD.

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Abbreviations

ACA:

Anterior cerebral artery

AUC:

Area under the curve

CSF:

Cerebrospinal fluid

FSE:

Fast spin echo

ICA:

Internal carotid artery

MCA:

Middle cerebral artery

MIP:

Maximum intensity projection

MMD:

Moyamoya disease

MMVs:

Moyamoya vessels

MR:

Magnetic resonance

MRA:

Magnetic resonance angiography

MRI:

Magnetic resonance imaging

ROC:

Receiver operating characteristic

SNR:

Signal-to-noise ratio

SWI:

Susceptibility-weighted imaging

T2WI:

T2-weighted imaging

TOF:

Time-of-flight

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan

    Takeshi Sawada, Akira Yamamoto, Tomohisa Okada, Mitsunori Kanagaki, Seiko Kasahara & Kaori Togashi

  2. Department of Radiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

    Yukio Miki

  3. Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, Fukui University, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan

    Ken-ichiro Kikuta

  4. Department of Neurosurgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan

    Susumu Miyamoto & Jun C. Takahashi

  5. Human Brain Research Center, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan

    Hidenao Fukuyama

Authors
  1. Takeshi Sawada
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  2. Akira Yamamoto
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  3. Yukio Miki
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  8. Susumu Miyamoto
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  11. Kaori Togashi
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Corresponding author

Correspondence to Akira Yamamoto.

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Sawada, T., Yamamoto, A., Miki, Y. et al. Diagnosis of moyamoya disease using 3-T MRI and MRA: value of cisternal moyamoya vessels. Neuroradiology 54, 1089–1097 (2012). https://doi.org/10.1007/s00234-012-1020-1

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  • DOI: https://doi.org/10.1007/s00234-012-1020-1

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