Abstract
Introduction
The dentatorubrothalamic tract (DRTT) originates from the dentate nucleus in the cerebellum and terminates in the contralateral ventrolateral nucleus (VL) of the thalamus after decussating to the contralateral red nucleus. Identification of the DRTT is difficult due to the fact that it is a long, multisynaptic, neural tract crossing to the opposite hemisphere. In the current study, we attempted to identify the DRTT in the human brain using a probabilistic tractography technique of diffusion tensor imaging.
Methods
Diffusion tensor imaging was performed at 1.5-T using a synergy-L sensitivity encoding head coil. DRTTs were obtained by selection of fibers passing through three regions of interest (the dentate nucleus, the superior cerebellar peduncle, and the contralateral red nucleus) from 41 healthy volunteers. Probabilistic mapping was obtained from the highest probabilistic location at 2.3 mm above the anterior commissure–posterior commissure level.
Results
DRTTs of all subjects, which originated from the dentate nucleus, ascended through the junction of the superior cerebellar peduncle and the contralateral red nucleus and then terminated at the VL nucleus of the thalamus. The highest probabilistic location for the DRTT at the thalamus was compatible with the location of the VL nucleus.
Conclusions
We identified the DRTT in the human brain using probabilistic tractography. Our results could be useful in research on movement control.
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References
Afifi AK, Bergman RA (2005) Functional neuroanatomy: text and atlas, 2nd edn. Lange Medical Books/McGraw-Hill, New York
Mendoza JE, Foundas AL (2007) Clinical neuroanatomy: a neurobehavioral approach. Springer, New York
Marx JJ, Iannetti GD, Thomke F et al (2008) Topodiagnostic implications of hemiataxia: an MRI-based brainstem mapping analysis. Neuroimage 39:1625–1632
Lehericy S, Grand S, Pollak P et al (2001) Clinical characteristics and topography of lesions in movement disorders due to thalamic lesions. Neurology 57:1055–1066
Mori S, Crain BJ, Chacko VP et al (1999) Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 45:265–269
Yamada K, Nagakane Y, Yoshikawa K et al (2007) Somatotopic organization of thalamocortical projection fibers as assessed with MR tractography. Radiology 242:840–845
Wakana S, Jiang H, Nagae-Poetscher LM et al (2004) Fiber tract-based atlas of human white matter anatomy. Radiology 230:77–87
Hong JH, Son SM, Jang SH (2010) Somatotopic location of corticospinal tract at pons in human brain: a diffusion tensor tractography study. Neuroimage 51:952–955
Yang DS, Hong JH, Byun WM et al (2009) Identification of the medial lemniscus in the human brain: combined study of functional MRI and diffusion tensor tractography. Neurosci Lett 459:19–24
Concha L, Gross DW, Beaulieu C (2005) Diffusion tensor tractography of the limbic system. AJNR Am J Neuroradiol 26:2267–2274
Habas C, Cabanis EA (2007) Cortical projection to the human red nucleus: complementary results with probabilistic tractography at 3 T. Neuroradiology 49:777–784
Habas C, Cabanis EA (2007) Anatomical parcellation of the brainstem and cerebellar white matter: A preliminary probabilistic tractography study at 3 T. Neuroradiology 49:849–863
Yamada K, Akazawa K, Yuen S et al (2010) MR imaging of ventral thalamic nuclei. AJNR Am J Neuroradiol 31:732–735
Nilsson C, Markenroth Bloch K, Brockstedt S et al (2007) Tracking the neurodegeneration of parkinsonian disorders—a pilot study. Neuroradiology 49:111–119
Hong JH, Kim OL, Kim SH et al (2009) Cerebellar peduncle injury in patients with ataxia following diffuse axonal injury. Brain Res Bull 80:30–35
Wang F, Sun Z, Du X et al (2003) A diffusion tensor imaging study of middle and superior cerebellar peduncle in male patients with schizophrenia. Neurosci Lett 348:135–138
Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113
Behrens TE, Johansen-Berg H, Woolrich MW et al (2003) Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6:750–757
Behrens TE, Berg HJ, Jbabdi S et al (2007) Probabilistic diffusion tractography with multiple fibre orientations: what can we gain? Neuroimage 34:144–155
Smith SM, Jenkinson M, Woolrich MW et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23(Suppl 1):S208–S219
Akazawa K, Yamada K, Matsushima S et al (2010) Optimum b value for resolving crossing fibers: a study with standard clinical b value using 1.5-T MR. Neuroradiology 52:723–728
Salamon N, Sicotte N, Drain A et al (2007) White matter fiber tractography and color mapping of the normal human cerebellum with diffusion tensor imaging. J Neuroradiol 34:115–128
Lenz FA, Kwan HC, Martin RL et al (1994) Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells. Brain 117(Pt 3):531–543
Jankovic J, Hamilton WJ, Grossman RG (1997) Thalamic surgery for movement disorders. Adv Neurol 74:221–233
Lenz FA, Normand SL, Kwan HC et al (1995) Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. Mov Disord 10:318–328
Ohye C, Shibazaki T, Hirai T et al (1993) Tremor-mediating thalamic zone studied in humans and in monkeys. Stereotact Funct Neurosurg 60:136–145
Morel A, Magnin M, Jeanmonod D (1997) Multiarchitectonic and stereotactic atlas of the human thalamus. J Comp Neurol 387:588–630
Yamada K, Sakai K, Akazawa K et al (2009) MR tractography: a review of its clinical applications. Magn Reson Med Sci 8:165–174
Parker GJ, Alexander DC (2005) Probabilistic anatomical connectivity derived from the microscopic persistent angular structure of cerebral tissue. Philos Trans R Soc Lond B Biol Sci 360:893–902
Stieltjes B, Kaufmann WE, van Zijl PC et al (2001) Diffusion tensor imaging and axonal tracking in the human brainstem. Neuroimage 14:723–735
Acknowledgment
This work was supported by a National Research Foundation of Korea grant funded by the Korean Government (no. KRF-2008-314-E00173)
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We declare that we have no conflict of interest.
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Kwon, H.G., Hong, J.H., Hong, C.P. et al. Dentatorubrothalamic tract in human brain: diffusion tensor tractography study. Neuroradiology 53, 787–791 (2011). https://doi.org/10.1007/s00234-011-0878-7
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DOI: https://doi.org/10.1007/s00234-011-0878-7