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Diagnostic examination performance by using microvascular leakage, cerebral blood volume, and blood flow derived from 3-T dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in the differentiation of glioblastoma multiforme and brain metastasis

  • Diagnostic Neuroradiology
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Abstract

Introduction

Conventional magnetic resonance (MR) imaging has limited capacity to differentiate between glioblastoma multiforme (GBM) and metastasis. The purposes of this study were: (1) to compare microvascular leakage (MVL), cerebral blood volume (CBV), and blood flow (CBF) in the distinction of metastasis from GBM using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC-MRI), and (2) to estimate the diagnostic accuracy of perfusion and permeability MR imaging.

Methods

A prospective study of 61 patients (40 GBMs and 21 metastases) was performed at 3 T using DSC-MRI. Normalized rCBV and rCBF from tumoral (rCBVt, rCBFt), peri-enhancing region (rCBVe, rCBFe), and by dividing the value in the tumor by the value in the peri-enhancing region (rCBVt/e, rCBFt/e), as well as MVL were calculated. Hemodynamic and histopathologic variables were analyzed statistically and Spearman/Pearson correlations. Receiver operating characteristic curve analysis was performed for each of the variables.

Results

The rCBVe, rCBFe, and MVL were significantly greater in GBMs compared with those of metastases. The optimal cutoff value for differentiating GBM from metastasis was 0.80 which implies a sensitivity of 95%, a specificity of 92%, a positive predictive value of 86%, and a negative predictive value of 97% for rCBVe ratio. We found a modest correlation between rCBVt and rCBFt ratios.

Conclusion

MVL measurements in GBMs are significantly higher than those in metastases. Statistically, both rCBVe, rCBVt/e and rCBFe, rCBFt/e were useful in differentiating between GBMs and metastases, supporting the hypothesis that perfusion MR imaging can detect infiltration of tumor cells in the peri-enhancing region.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Section of Neuroradiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway

    Andrés Server & Per H. Nakstad

  2. University of Oslo, Oslo, Norway

    Andrés Server & Per H. Nakstad

  3. Interventional Centre, Oslo University Hospital, Oslo, Norway

    Tone E. Døli Orheim

  4. Department of Radiology and Nuclear Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway

    Bjørn A. Graff

  5. Department of Neurosurgery, Oslo University Hospital-Ullevaal, Oslo, Norway

    Roger Josefsen

  6. Department of Pathology, Oslo University Hospital-Ullevaal, Oslo, Norway

    Theresa Kumar

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  1. Andrés Server
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Server, A., Orheim, T.E.D., Graff, B.A. et al. Diagnostic examination performance by using microvascular leakage, cerebral blood volume, and blood flow derived from 3-T dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in the differentiation of glioblastoma multiforme and brain metastasis. Neuroradiology 53, 319–330 (2011). https://doi.org/10.1007/s00234-010-0740-3

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  • DOI: https://doi.org/10.1007/s00234-010-0740-3

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