Abstract.
The application of molecular biology to the study of electroneutral cation-chloride cotransporters has been extremely successful, resulting in the identification of a new gene family of five membrane proteins. The function, expression, and regulation of these important proteins can increasingly be described in molecular terms. In addition, mutations in two renal cation-chloride transporter genes have been found in patients with Bartter's and Gitelman's syndromes, autosomal recessive disorders of renal salt excretion.
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Received: 14 February 1997
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Mount, D., Hoover, R. & Hebert, S. The Molecular Physiology of Electroneutral Cation-Chloride Cotransport . J. Membrane Biol. 158 , 177 –186 (1997). https://doi.org/10.1007/s002329900255
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DOI: https://doi.org/10.1007/s002329900255